Betula - åldrande, minne och demens
Betulaprojektet är en longitudinell studie av åldrande, minne och demens. Insamlingen till projektet skedde i sex vågor mellan 1988–2014: 1988–1990 (testvåg 1); 1993–1995 (testvåg 2); 1998–2000 (testvåg 3); 2003–2005 (testvåg 4); 2008–2010 (testvåg 5); 2013–2014 (testvåg 6). Vid varje testtillfälle har varje deltagare genomgått en noggrann hälsoundersökning med blodprovstagning hos en sjuksköterska och en noggrann undersökning hos en minnestestare. Det finns data insamlat från ca 4700 deltagare. Vid varje tillfälle insamlas data för ungefär 2000 variabler för varje deltagare som inkluderar data om demografi, hälsa, sjukdom, medicinering, sociala faktorer och kognitiva faktorer. Betulaprojektet har fått bidrag för forskningsinfrastruktur (stora databaser) från Vetenskapsrådet. Det innebär en kraftig satsning på att bygga upp databasen för Betula och göra databasen tillgänglig även för forskare utanför projektet i form av samarbeten med forskare direkt kopplade till Betulaprojektet. Till Betulas databas är även kopplad gendata och biologiska prov. Syfte: Studera hur minnesfunktioner förändras under vuxenlivet, att bestämma riskfaktorer för demens och tidigare prekliniska tecken på demens och att bestämma vilka de kritiska faktorerna av det goda åldrandet är.
Citering och åtkomst
Citering och åtkomst
Skapare/primärforskare:
Forskningshuvudman:
Data innehåller personuppgifter:
Ja
Typ av personuppgifter:
Pseudonymiserade data
Kodnyckel existerar:
Ja
Data innehåller känsliga personuppgifter:
Ja
Citering:
Tillgänglighetsnivå:
Metod och utfall
Metod och utfall
Analysenhet:
Population:
Personer i åldersgrupper mellan 25-80 år bosatta i Umeå kommun.
Studiedesign:
- Observationsstudie
- Kohortstudie
- Kohortstudie: Prospektiv
Beskrivning av studiedesign:
Studien startade med 1000 slumpmässigt utvalda personer i Umeås kommun som inkluderades från åldersgrupperna 35, 40, 45, 50, 55, 60, 65, 70, 75 och 80 år. Det var 100 i varje ålderskohort och könsfördelningen såg ut ungefär som i populationen dvs ungefär lika många män som kvinnor i de yngre åldersgrupperna och ungefär dubbelt så många kvinnor som män i åldersgrupperna 70 och uppåt. Under studiens gång rekryterades ytterligare fem sample i olika omgångar som sträckte sig mellan åldersgrupperna 25-95 år.
Urvalsmetod:
Beskrivning av urval:
1000 personer i åldersgrupperna 35, 40, 45, 50, 55, 60, 65, 70, 75 och 80 blev slumpmässigt utvalda (sample 1, S1). Det ingick 100 personer i varje ålderskohort, könsfördelningen avspeglade könsfördelningen i populationen d.v.s ungefär lika många män som kvinnor i de yngre åldrarna, ungefär dubbelt så många kvinnor som män från åldersgruppen 70 och uppåt (testtillfälle 1, T1). Vid T2, fem år senare, inkallades ytterligare två sample, S2 (ca 1000 st, 35-80 år) och S3 (ca 960 st, 40-85 år). Vid T3 kallades sample 4 in (ca 500st, 35-90 år). Vid T4, kallades sampel 5 in (ca 500 st, 35-95 år) och vid T5 kallades sample 6 (ca 350st, 25-80 år).
Tidsperiod(er) som undersökts:
Datainsamlingar - 6 insamlingar
Datainsamlingar - 6 insamlingar
Datainsamling
Datainsamling
Beskrivning av insamlingsmetod:
Psykologiska mätningar och tester, fysiska mätningar och tester, samt självadministrerade frågeformulär.
Tidsperiod(er) för datainsamling:
1988 - 1990
Datainsamling
Datainsamling
Beskrivning av insamlingsmetod:
Psykologiska mätningar och tester, fysiska mätningar och tester, samt självadministrerade frågeformulär.
Tidsperiod(er) för datainsamling:
1993 - 1995
Datainsamling
Datainsamling
Beskrivning av insamlingsmetod:
Psykologiska mätningar och tester, fysiska mätningar och tester, samt självadministrerade frågeformulär.
Tidsperiod(er) för datainsamling:
1998 - 2000
Datainsamling
Datainsamling
Beskrivning av insamlingsmetod:
Psykologiska mätningar och tester, fysiska mätningar och tester, samt självadministrerade frågeformulär.
Tidsperiod(er) för datainsamling:
2003 - 2005
Datainsamling
Datainsamling
Beskrivning av insamlingsmetod:
Psykologiska mätningar och tester, fysiska mätningar och tester, samt självadministrerade frågeformulär.
Tidsperiod(er) för datainsamling:
2008 - 2010
Datainsamling
Datainsamling
Beskrivning av insamlingsmetod:
Psykologiska mätningar och tester, fysiska mätningar och tester, samt självadministrerade frågeformulär.
Tidsperiod(er) för datainsamling:
2013 - 2014
Geografisk täckning
Geografisk täckning
Geografisk plats:
Geografisk beskrivning:
Umeå kommun
Administrativ information
Administrativ information
Ansvarig institution/enhet:
Institutionen för integrativ medicinsk biologi (IMB)
Etikprövning 1:
Umeå - 97-173 (§7/870303)
Etikprövning 2:
Umeå - 03-484
Etikprövning 3:
Umeå - 2013-92-31M
Etikprövning 4:
Umeå - 08-132
Finansiering
Finansiering
Finansiär:
- Vetenskapsrådet
Öppnar nytt fönster hos ror.org.
RORÖppnas i en ny tabb
Diarienummer hos finansiär:
K2010-61X-21446-01
Finansiär:
- Knut och Alice Wallenberg Stiftelse (KAW)
Öppnar nytt fönster hos ror.org.
RORÖppnas i en ny tabb
Ämnesområde och nyckelord
Ämnesområde och nyckelord
Standard för svensk indelning av forskningsämnen 2011:
CESSDA Topic Classification:
Nyckelord:
Publikationer
Publikationer
Citering:
Nixon Andreasson, A., Szulkin, R., Undén, A.-L., von Essen, J., Nilsson, L.-G., & Lekander, M. (in press). Inflammation and positive affect related to subjective health: Women from the general population. Health Psychology.
Citering:
Pickard B.S., Van Den Bossche M.J., Malloy M.P., Johnstone M., Lenaerts A.S., Nordin A., Goossens D., St Clair D., Muir W.J., Nilsson L.-G., Sabbe B., Adolfsson R., Blackwood D.H., & Del-Favero J. (in press). Multiplex amplicon quantification screening the ABCA13 gene for copy number variation in schizophrenia and bipolar disorder. Psychiatric Genetics. 2012 Mar 1. [Epub ahead of print]
Citering:
Mousavi-Nasab, S.-M. H., Kormi-Nouri, R., Sundström, A., & Nilsson, L.-G. (2012) The effects of marital status on episodic and semantic memory in healthy middle-aged and old individuals. Scandinavian Journal of Psychology, 53, 1-8. Doi: 10.1111/j.1467-9450.2011.00926.x
Citering:
Salami, A., Eriksson, J., Nyberg, L., & Nilsson, L.-G. (2012). Age-related white matter microsctructural differences are not major mediators of cognitive decline in aging. Biochemica et Biophysica Acta-Molecular Basis of Disease, 1822, 408-415. Doi: 10.1016/jbbadis.2011.09.001.
Citering:
Wikgren, M., Karlsson, T., Nilbrink, T., Nordfjäll, K., Hultdin, J., Sleegers, K., Van Broeckhoven, C., Nyberg, L., Roos, G., Nilsson, L.-G., Adolfsson, R., & Norrback, K.-F. (2012). APOE e4 is associated with longer telomeres, and longer telomeres among e4 carriers predicts worse episodic memory. Neurobiology of Aging, 33, 335-344. Doi: 10.1016/j.neurobiolaging.2010.03.004.
Citering:
Wikgren, M., Maripuu, M., Karlsson, T., Nordfjäll, K., Bergdahl, J., Hultdin, J., Del-Favero, J., Roos, G., Nilsson, L.-G., Adolfsson, R., & Norrback, K.-F. (2012). Short telomeres in depression and the general population are associated with hypocortisolemic state. Biological Psychiatry, 71, 294-300. Doi: 10.1016/j.biopsych.2011.09.015.
Citering:
Ceulemans, S., De Zutter, S., Heyrman, L., Norrback, K.-F., Nordin, A., Nilsson, L.-G., Adolfsson, R., Del-Favero, J., & Claes, S. (2011). Evidence for the involvement of the glucocorticoid receptor gene in bipolar disorder in an isolated Swedish population. Bipolar Disorders, 13, 614-623. Doi: 10.1111/j.1399-5618.2011.00960.x.
Citering:
Hedner, M., Nilsson, L.-G., Olofsson, J.K., Bergman, O., Eriksson, E., Nyberg, L., & Larsson, M. (2011). Age-related olfactory decline is associated with the val66met polymorphism: Evidence from a population-based study. Frontiers of Cognitive Aging: Neoroscience. Doi: 10.3389/fnagi.2010.00024.
Citering:
Kauppi, K., Nilsson, L.-G., Adolfsson, R., Eriksson, E., & Nyberg, L. (2011). KIBRA polymorphism is related to enhanced memory and elevated hippocampal processing. Journal of Neuroscience, 40, 14218-14222. Doi: 10.1523/jneurosci.3292-11.2011.
Citering:
Kompus, K., Westerhausen, R., Nilsson, L.-G., Hugdahl, K., Jongstra, S., Berglund, A., Arver, S., & Savic, I. (2011). Deficits in inhibitory executive functions in Klinefelter (47, XXY) syndrome. Psychiatry Research, 189, 135-140. Doi: 10.1016/jpsychres.201102.028.
Citering:
Lekander, M., von Essen, J., Schultzberg, M., Nixon Andreasson, A., Garlind, A., Hansson, L.-O., & Nilsson, L.-g. (2011). Cytokines and memory across the mature life span of women. Scandinavian Journal of Psychology, 52, 229-235. Doi: 10.1111/j.1467-9450.2010.00865.x.
Citering:
Moens, L.N., De Rijk, P., Reumers, J., Van den Bossche, M.J.A., Glassee, W., De Zutter, S., Lenaerts, A.S., Nordin, A., Nilsson, L.-G., Castello, I.M., Norrback, K.F., Goossens, D., Van Steen, K., Adolfsson, R., & Del-Favero, J. (2011). Sequencing of DISC1 patheway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population. PlosONE, 6. Doi: 10.1371/journal.pone.0023450.
Citering:
Nilsson, L.-G. (2011). Genetic and demographic factors related to successful aging. Frontiers in Human Neuroscience. Conference Abstract: XI International Conference on Cognitive Neuroscience (ICON XI). Doi: 10.3389/conf.fnhum.2011.207.00593
Citering:
Persson, J., Kalpouzos, G., Nilsson, L.-G., Ryberg, M., & Nyberg, L. (2011). Preserved hippocampus activation in normal aging as revealed by fMRI. Hippocampus, 21, 753-766. Doi: 10.1002/hipo.20794.
Citering:
Rönnberg, J., Danielsson, H., Rudner, M., Arlinger, S., Sternäng, O., Wahlin, Å., & Nilsson, L.-G. (2011). Hearing loss is negatively related to episodic and semantic long-term memory but not to short-term memory. Journal of Speech, Language, and Hearing Research, 54, 705-726. Doi: 10.1044/1092-4388(2010/09-0088).
Citering:
Sundström, A., Bergdahl, J., Nyberg, L., Bergdahl, M., & Nilsson, L.-G. (2011). Stressful negative life events and amalgam-related complaints. Community Dentistry and Oral Epidemiology, 39, 12-18. Doi: 10.1111/j.1600-0528.2010.00571.x
Citering:
Vestergren, P., & Nilsson, L.-G. (2011). Perceived causes of everyday memory problems in a population-based sample aged 39-99. Applied Cognitive Psychology, 25, 641-646. Doi: 10.1002/acp.1734.
Citering:
Vestergren, P., Rönnlund, M., Nyberg, L., & Nilsson, L.-G. (2011). Development of the Cognitive Dysfunction Questionnaire (CDQ) in a population based sample. Scandinavian Journal of Psychology, 52, 218-228. Doi: 10.1111/j.1467-9450.2010.00861.x.
Citering:
Backeström, A., Eriksson, S., Nilsson, L.-G., Nyberg, L., Olsson, T., & Rolandsson, O. (2010). Glucose metabolism and cognitive dysfunction. Diabeologia, 53, 730.
Citering:
Bergman, O., Westberg, L., Nilsson, L.-G., Adolfsson, R., & Eriksson, E. (2010). Preliminary evidence that polymorphisms in dopamine-related transcription factors LMX1A, LMX1B and PITX3 are associated with schizophrenia. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 34, 1094-1097.
Citering:
Danielsson, H., Henry, L., Rönnberg, J., & Nilsson, L.-G. (2010). Executive functions in individuals with intellectual disability. Research in Developmental Disabilities, 31, 1299-1304.
Citering:
Danielsson, H., Henry, L.A., Rönnberg, J., & Nilsson, L.-G. (2010). Selective problems in executive function in adults with ID: The Betula Database. Journal of Applied Research in Intellectual Disabilities, 23, 438-458.
Citering:
Eriksson, D., Nilsson, L.-G., Rönnlund, M., & Sundström, A. (2010). Effects of perceived long-term stress on health and memory functioning. Abstracts of the Psychonomic Society, 15, 78-78.
Citering:
de Frias, C.M., Marklund, P., Eriksson, E., Larsson, A., Öhman, L., Annerbrink, K., Bäckman, L., Nilsson, L.-G., & Nyberg, L. (2010). Influence of COMT gene polymorphism on fMRI-assessed sustained and transient activity during a working-memory task. Journal of Cognitive Neuroscience, 22, 1614-1622.
Citering:
Malmberg, G., Nilsson, L.-G., & Weinehall, L. (2010). Longitudinal data for interdiscipinary aging research. Scandinavian Journal of Public Health, 38, 761-767.
Citering:
Nilsson, L.-G. (2010). The Betula Study: Memory, ageing, health and dementia in Sweden. Public Service Review: European Union, 19, 130-131.
Citering:
Nyberg, L., Salami, A., Andersson, M., Eriksson, J., Kalpouzos, G., Kauppi, K., Lind, J., Pudas, S., Persson, J., & Nilsson, L.-G. (2010) Longitudinal evidence for diminished frontal-cortex function in aging. PNAS, 107, 22682-22686. Doi: 10.1073/pnas.1012651108.
Citering:
Olofsson, J.K., Nordin, S., Wiens, S., Hedner, M., Nilsson, L.-G., & Larssson, M. (2010). Odor identification impairment in carriers of ApoE-?4 is independent of dementia. Neurobiology of Aging, 31, 567-577.
Citering:
Sternäng, O., Jonsson, B., Wahlin, Å., Nyberg, L., & Nilsson, L.-G (2010). Examination of the common cause account in a population-based longitudinal study with narrow age cohort design. Gerontology, 56, 553-563.
Citering:
Sundström, A., Bergdahl, J., Nyberg, L., Bergdahl, M., & Nilsson, L.-G. (2010). Cognitive status in persons with Amalgam related complaints. Journal of Dental Research, 89, 1236-1240.
Citering:
Thilers, P.P., MacDonald, S.W., Nilsson, l.-G., & Herlitz, A. (2010). Accelerated postmenopausal cognitive decline is restricted to women ith normal BMI: Longitudinal evidence from the Betula project. Psychoneuroendocrinology, 35, 516-524.
Citering:
Naghavi, H.R., Lind, J., Nilsson, L.-G., Adolfsson, R., & Nyberg, L. (2009). Personality traits predict response to novel and familiar stimuli in the hippocampal region. Psychiatry Research: Neuroimaging, 173, 94-99
Citering:
Alaerts, M., Ceulemans, S., Forero, D., Moens, L.N., De Zutter, S., Heyman, L., Lenaerts, A.S., Norrback, K.F., Goossens, D., De Rijk, P., Nilsson, L.-G., Adolfsson, R., & Del-Favero, J. (2009). Detailed analysis of the serotonin transporter gene (SLC6A4) shows no association with bipolar disorder in the Northern Swedish population. American Journal of Medical Genetics: Neuropsychiatric Genetics, 150B, 585-592.
Citering:
Alaerts, M., Ceulemans, S., Forero, D., Moens, L.N., De Zutter, S., Heyman, L., Lenaerts, A.S., Norrback, K.F., De Rijk, P., Nilsson, L.-G., Goossens, D., Adolfsson, R., & Del-Favero, J. (2009). Support for NRG1 as a susceptibility factor for schizophrenia in a Northern Swedish isoated population. Archives of General Psychiatry, 66, 828-828
Citering:
Ballesteros, S., Nilsson, L.-G., & Lamaire, P. (2009). Ageing, cognition and neuroscience: An introduction. European Journal of Cognitive Psychology, 21, 161-175.
Citering:
Maitland, S.B., Nyberg, L., Bäckman, L., Nilsson, L.-G., & Adolfsson, R. (2009). The search for structure: The temperament character of the Temperament and Character Inventory. In C. Herzog (Ed.), Cognition and aging: Methodologies and applications. Washington, DC: American Psychological Association.
Citering:
Hedner, M., Nilsson, L.-G., Olofsson, J. et al. (2008). The BDNF Val66Met polymorphism influences olfactory processing. International Journal of Psychology, 43, 275-276.
Citering:
Maitland, S.B., Nyberg, L., Bäckman, L., Nilsson, L.-G., & Adolfsson, R. (2009). On the structure of personality: Are there separate temperament and character factors. Personality and Individual Differences, 47, 180-184.
Citering:
Nilsson, L.-G., Sternäng, O., Rönnlund, M., & Nyberg, L. (2009). Challenging the notion of an early-onset of cognitive aging. Neurobiology of Aging, 30, 521-524.
Citering:
Nyberg, L., Andersson, M., Forsgren, L., Jakobsson-Mo, S., Larsson, A., Marklund, P., Nilsson, L.-G., Riklund, K., & Bäckman, L- (2009). Striatal dopamine D2 binding is related to frontal BOLD response during updating of long-term memory representations. NeuroImage, 46, 1194-1199.
Citering:
Olofsson, J., Rönnlund, M., Nordin, S., Nyberg, L., Nilsson, L.-G., & Larsson, M. (2009). Odor identification deficit as a predictor of five-year global cognitive change: Interactive effects with age and ApoE-?4. Behavior Genetics, 39, 496-503.
Citering:
Rönnlund, M., & Nilsson, L-G. (2009). Flynn effects on sub-factors of episodic and semantic memory: Parallel gains over time and the same set of determining factors. Neuropsychologia, 11, 2174-2188.
Citering:
Bergdahl, M., Bergdahl, J., Nyberg, L., & Nilsson, L.-G. (2008). Difference I apolipoprotein E type 4 allele (APOE-?4) among dentate and edentulous subjects. Gerodontology, 25(3), 179-186
Citering:
de Frias, C.M., Bunce, D., Wahlin, Å., Adolfsson, R., Sleegers, K., Cruts, M., Van Broeckhoven, C., & Nilsson, L.-G. (2008). Cholesterol and triglycerides moderate the effect of apolipoprotein E on memory functioning in older adults. Journal of Gerontology: Psychological Sciences, 62, P112-P118.
Citering:
Hansson, P., Rönnlund, M., Juslin, P., & Nilsson, L.-G. (2008). Adult age diffeerences in the realism of confidence judgments: Overconfidence, formal dependence, and cognitive predictors. Psychology and Aging, 23(3), 531-544.
Citering:
Holmgren, S., Molander, B., & Nilsson, L.-G. (2008). Episodic memory in adult age and effects of sibship size and birth order: Longitudinal data. Journal of Adult Development, 14, 37-46.
Citering:
Kask, K., Bäckström, T., Nilsson, L.-G., & Sundström-Poromaa, I. (2008). Allopregnanolone impairs episodic memory in healthy women. Psychpharmacology, 199(2), 161-168.
Citering:
Kormi-Nouri, R., Shojaei, R.-S., Moniri, S., Gholami, A.-R., Moradi, A.-R., Akbari-Zardkhaneh, S., & Nilsson, L.-G. (2008). The effect of childhood bilingualism on episodic and semantic memory tasks. Scandinavian Journal of Psychology, 49(2), 93-109.
Citering:
Olofsson, J., Rönnlund, M., Nordin, S., et al. (2008). Odor identification impairment predicts cognitive decline and Alzheimer's disease. International Journal of Psychology, 43, 469-469.
Citering:
Persson, J., Lind, J., Larsson, A., Ingvar, M., Sleegers, K., Van Broeckhoven, C., Adolfsson, R., Nilsson, L.-G., & Nyberg, L. (2008). Altered deactivation in individuals with genetic risk for Alzheimer's disease. Neuropsychologia, 46, 1679-1687.
Citering:
Rolandsson, O., Backeström, A., Eriksson, S., Hallmans, G., & Nilsson, L.-G. (2008). Increased glucose levels are associated with episodic memory in nondiabetic women. Diabetes, 57, 440-443.
Citering:
Rönnlund, M., Lövdén, M., & Nilsson, L.-G. (2008). Cross-Sectional versus Longitudinal Age Gradients of Tower of Hanoi Performance: The Role of Practice Effects and Cohort Differences in Education. Aging, Neuropsychology and Cognition, 15, 40-67
Citering:
Rönnlund, M., Mäntylä, T., & Nilsson, L.-G. (2008). The prospective and retrospective memory questionnaire (PRMQ): Factorial structure, relations to global subjective memory ratings, and Swedish norms. Scandinavian Journal of Psychology, 49, 11-18.
Citering:
Rönnlund, M., & Nilsson, L.-G. (2008). The magnitude, generality, and determinants of Flynn effects on forms of declarative memory and visuospatial ability: Time-sequential analyses of data from a Swedish cohort study. Intelligence, 36, 192-209.
Citering:
Sternäng, O., Wahlin, Å., & Nilsson, L.- G. (2008). Examination of the processing speed account in a population-based longitudinal study with narrow age cohort design. Scandinavian Journal of Psychology, 49(5), 419-428
Citering:
Sundström, A., Nilsson, L.-G., Cruts, M., Adolfsson, R., Van Broeckhoven, C., & Nyberg, L. (2008). Fatigue before and after mild traumatic brain injury: Pre-post-injury comparisons in relation to ApolipoproteinE. Brain Injury, 1-6.
Citering:
Wahlin, Å., Anstey, K., McDonald, S.W.S., Ahmed, S.M., Kivipelto, M., Kunnukattil, K.S.S., Mai, T.T., Nilsson, L.-G., Streatfield, P.K., van Boxtel, M.P., & Kabir, Z.N. (2008). The international network on public health and aging (INOPA): Introducing a life course perspective to the public health agenda. Journal of Cross-Cultural Gerontology, 23(1), 97-105.
Citering:
Zhang, Y.M., Han, B., & Nilsson, L.-G. (2008). Executive functioning in older adults with mild cognitive impairment: MCI has effects on planning, but not on inhibition: Erratum. Aging, Neuropsychology and Cognition, 15(2), 256-256.
Citering:
Bergdahl, M., Habib, R., Bergdahl, J., Nyberg, L., & Nilsson, L.-G. (2007). Natural teeth and cognitive function in humans. Scandinavian Journal of Psychology, 48, 557-568.
Citering:
de Frias, C. M., Lövdén, M., Lindenberger, U., & Nilsson, L.-G. (2007). Revisiting the dedifferention hypothesis with longitudinal multi-cohort data. Intelligence, 35, 381-392.
Citering:
Habib, R., Nyberg, L., & Nilsson, L.-G. (2007). Cognitive and non-cognitive factors contributing to the longitudinal identification of successful older adults in the Betula study. Aging, Neuropsychology and Cognition, 14, 257-273.
Citering:
Meyer, T. D., Hammelstein, P., Nilsson, L.-G., Skeppar, P., Adolfsson, R., & Angst, J. (2007). The Hypomania Checklist (HCL-32): Its factorial structure and association to indices of impairment in German and Swedish nonclinical samples. Comprehensive Psychiatry, 48, 79-87.
Citering:
Nilsson, L.-G., & Larsson, M. (2007). Objective and subjective memory function for men and women in adulthood and old age. In S. Magnussen & T. Helstrup (Eds.), Everyday memory, pp. 275-290. London: Psychology Press
Citering:
Sundström, A., Nilsson, L.-G., Cruts, M., Adolfsson, R., Van Broeckhoven, C., & Nyberg, L. (2007). Increased risk of dementia following mild head injury for carriers but not for non-carriers of the APOE-?4 allele. International Psychgeriatrics, 19, 159-165.
Citering:
Van Den Eede, F., Venken, T., Del-Favero, J., Norrback, K.-F., Souery, D., Nilsson, L.-G., Van den Bossche, B., Houlstijn, W., Sabbe, B. G. C., Cosyns, P., Mendlewicz, J., Adolfsson, R., Van Broeckhoven, C., & Claes, S. J. (2007). Single nucleotide polymorphism analysis of corticotropin-releasing factor-binding protein gene in recurrent major depressive disorder. Psychiatry Research, 153, 17-25.
Citering:
Van Den Eede, F., Venken, T., Van Den Bogaert, A., Del-Favero, J., Norrback, K.-F., Nilsson, L.-G., Adolfsson, R., Van Broeckhoven, C., & Claes, S. J. (2007). Single nucleotide polymorphism analysis of corticotropin-releasing factor-binding protein gene in bipolar disorder. Psychiatry Genetics, 17, 304-307.
Citering:
Öhman, L., Bergdahl, J., Nyberg, L., & Nilsson, L.-G. (2007). Longitudinal analysis of the relation between moderate long-term stress and health. Stress and Health, 23, 131-138.
Citering:
de Frias, C.M., Nilsson, L.-G., & Herlitz, A. (2006). Sex differences in cognition are stable over a 10-year period in adulthood and old age. Aging, Neuropsychology and Cognition, 13, 574-587.
Citering:
Holmgren, S., Molander, B., & Nilsson, L.-G. (2006). Intelligence in adult age: Effects of sibship size and birth order. European Journal of Cognitive Psychology, 18, 138-158.
Citering:
Launer, L.J., Berger, K., Breteler, M.M.B., Dufoil, C., Fuhrer, R., Giampoli, S., Nilsson, L.-G., Pajak, A., de Ridder, M., van Dijk, E.J., Sans, S., Schmidt, R., & Hofman, A. (2006). Regional variability in the prevalence of cerebral white matter lesions: An MRI study in 9 European countries (CASCADE). Neuroepidemiology. 26, 23-29.
Citering:
Lind, J., Ingvar, M., Persson, J., Cruts, M., Van Broeckhoven, C., Adolfsson, R., & Nilsson, L.-G. (2006). Parietal cortex activation predicts longitudinal memory decline in APOE-?4 carriers. NeuroReport, 17, 1683-1686.
Citering:
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