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A multimodal brain imaging dataset on sleep deprivation in young and old humans: The Sleepy Brain Study 1, version 3

https://doi.org/10.5878/87y5-kh22
The Stockholm Sleepy Brain Study I is a functional brain imaging study of 48 younger (20-30 years) and 36 older (65-75 years) healthy participants, with magnetic resonance imaging after normal sleep and partial sleep deprivation in a crossover design. We performed experiments investigating emotional mimicry, empathy for pain, and cognitive reappraisal, as well as resting state functional magnetic resonance imaging (fMRI). We also acquired T1- and T2-weighted structural images and diffusion tensor images (DTI). On the night before imaging, participants were monitored with ambulatory polysomnography and were instructed to sleep either as usual or only three hours. Participants came to the scanner the following evening. Besides MRI scanning, participants underwent behavioral tests and contributed blood samples, which have been stored in a biobank and used for DNA analyses. Participants also completed a variety of self-report measures. The resulting multimodal dataset may be useful for hypothesis generation or independent validation of effects of sleep deprivation and aging, as well as investigation of cross-sectional associations between the different outcomes. A full description of study design and procedures is available at: https://openarchive.ki.se/xmlui/handle/10616/45181Opens in a new tab The dataset is available for download with the tool Datalad (https://www.datalad.orgOpens in a new tab). The command after installing Datalad is: datalad install -r https://github.com/NilsonneData/SleepyBrain1.gitOpens in a new tab Earlier versions of this dataset can be found here: https://openneuro.org/datasets/ds000201/versions/1.0.3Opens in a new tab
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Documentation files

  • dataset_description.json
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  • README.txt
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Citation and access

Data access level:

Creator/​Principal investigator(s):

Research principal:

Data contains personal data:

No

Citation:

License:

Language:

Method and outcome

Unit of analysis:

Population:

Healthy volunteers

Study design:

  • Double-blind randomised trial
  • Randomised controlled trial (RCT)
  • Experimental study

Time period(s) investigated:

Number of individuals/​objects:

90

Data format/​data structure:

Data collection Measurements and tests

Mode of collection:

Measurements and tests

Data collector:

Source of the data:

  • Other

Administrative information

Responsible department/​unit:

Department of Clinical Neuroscience [K8]

Contributor(s):

Ethics Review:

Stockholm - 2012/1098-31/2

Funding

Funding agency:

Award number:

2014-00037, 2015-00170

Funding agency:

Award number:

P15-0310:1_RJ

Award title:

The role of sleep in emotional processing and social functioning

Funding information:

Disturbed sleep is common and causes increased risks for psychiatric morbidity as well as worse subjective emotional experience. Emotional processing and regulation is important for maintaining adequate function at work and in private life. Brain mechanisms for emotional processing and social functioning is increasingly well known thanks to functional brain imaging. Our experience of others emotional states appear to be represented hierarchically in the brain. The simplest level of representation is emotional mimicry. On a higher level, empathy is a representation where one is aware that the other s emotional state is primary. Cognitive regulation and reappraisal represents the highest level of regulation. Using functional magnetic resonance imaging (fMRI), we can identify outcomes pertaining to processing in the brain on these three levels. This project encompasses three experimental studies with functional brain imaging. In study 1, we will investigate the effect of sleep loss on emotional processing. In study 2, we will investigate the effect of sleep loss on brain activity as well as social behaviour. In study 3, we will investigate the role of sleep quality in recovery by suppressing specific sleep stages. The project is novel and important in that it connects sleep loss to subjective and objective measures not only of social emotions but also highly relevant measures of social behaviour.

Topic and keywords

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Keywords:

Relations

References:

PreregistrationOpens in a new tab

Obsoletes:

Dataset at openneuro.orgOpens in a new tab

Related resource:

Brain Imaging Data SpecificationOpens in a new tab

Publications

Citation:

Åkerstedt T, Lekander M, Nilsonne G, Tamm S, d’Onofrio P, Kecklund G, Fischer H, Schwarz J, Petrovic P, Månsson KNT. Gray matter volume correlates of sleepiness: a voxel–based morphometry study in younger and older adults. Nature and Science of Sleep 2020, 12, 289-198.

Citation:

Nilsonne G, Tamm S, d’Onofrio P, Thuné HÅ, Schwarz J, Lavebratt C, Liu, JJ, Månsson KNT, Sundelin T, Axelsson J, Fransson P, Kecklund G, Fischer H, Lekander M, Åkerstedt Torbjörn. A multimodal brain imaging dataset on sleep deprivation in young and old humans. Karolinska Open Archive. url: http://hdl.handle.net/10616/45181Opens in a new tab

Citation:

Koba C, Notaro G, Tamm S, Nilsonne G, Hasson U. Spontaneous eye-movements during eyes-open rest reduce resting-state-network modularity by increasing visual-sensorimotor connectivity. bioRχiv. doi: 10.1101/2020.05.18.100669

Citation:

Åkerstedt T, Lekander M, Nilsonne G, Tamm S, d’Onofrio P, Kecklund G, Fischer H, Schwarz J. Effects of late night short sleep on in-home polysomnography – relation to adult age and sex. Journal of Sleep Research 2017. doi: 10.1111/jsr.12626

Citation:

Tamm S, Nilsonne G, Lamm C, Kecklund G, Petrovic P, Fischer H, Åkerstedt T, Lekander M. The effect of sleep restriction on empathy for pain: An fMRI study in younger and older adults. Scientific Reports 2017 7:12236. doi: 10.1038/s41598-017-12098-9

Citation:

Tamm S, Nilsonne G, Schwarz J, Golkar A, Kecklund G, Petrovic P, Fischer H, Åkerstedt T, Lekander M. Sleep restriction caused impaired emotional regulation without detectable brain activation changes – a functional magnetic resonance imaging study. Royal Society Open Science, 6(3), 181704. doi: 10.1098/rsos.181704

Citation:

Nilsonne G, Tamm S, Schwarz J, Almeida R, Fischer H, Kecklund G, Lekander M, Fransson P, Åkerstedt T. Intrinsic brain connectivity after partial sleep deprivation in young and older adults: results from the Stockholm Sleepy Brain Study. Scientific Reports 2017 7:9422. doi: 10.1038/s41598-017-09744-7

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Metadata

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