Data generated for "Serial MRD assessment predicts relapse after transplantation in patients with myelodysplastic syndrome.
https://doi.org/10.48723/hk61-4f76
The study has evaluated the association between measurable residual disease (MRD) determined using digital droplet PCR (ddPCR) and outcome after allogeneic stem cell transplantation for patients with myelodysplastic syndrome (MDS). The patient-specific mutations have been identified using next generation sequencing (NGS).
The dataset contains:
1. NGS data
2. MRD data
3. List of ddPCR-assays
4. Variants for ddPCR only identified at diagnosis
5. Variants of undetermined significance targeted by ddPCR
6. Regression analyses
Citation and access
Citation and access
Data access level:
Creator/Principal investigator(s):
Research principal:
Data contains personal data:
Yes
Type of personal data:
Medicinska data
Code key exists:
Yes
Sensitive personal data:
Yes
Citation:
Language:
Method and outcome
Method and outcome
Unit of analysis:
Population:
Patients with MDS who has undergone allogeneic stem cell transplantation
Study design:
- Diagnostic study
Description of study design:
Bone marrow and peripheral blood samples were collected a different time points after allogeneic stem cell transplantation. Measurable residual disease (MRD) were analyzed using digital droplet PCR for patient specific mutations. The association between MRD and relapse was investigated.
Sampling procedure:
Description of sampling:
All MDS-patients planned for allogeneic stem cell transplantation were asked for participation
Time period(s) investigated:
Number of individuals/objects:
266
Samples/material - Collected from scientific collection/biobank
Samples/material - Collected from scientific collection/biobank
Name:
KI biobank
Type(s) of sample:
Bone marrow and blood
Administrative information
Administrative information
Responsible department/unit:
Department of Medicine, Huddinge [H7]
Other research principals:
Contributor(s):
Ethics Review:
Stockholm - 2015-2254/31
Funding
Funding
Funding agency:
- Swedish Research Council
Opens a new window at ror.org.
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Award number:
2021-01404_VR
Topic and keywords
Topic and keywords
Standard för svensk indelning av forskningsämnen 2025:
Publications
Publications
Citation:
Tobiasson, M., Pandzic, T., Illman, J., Nilsson, L., Weström, S., Ejerblad, E., Olesen, G., Björklund, A., Olsnes Kittang, A., Werlenius, O., Lorentz, F., Rasmussen, B., Cammenga, J., Weber, D., Lindholm, C., Wiggh, J., Dimitriou, M., Moen, A. E., Yip Lundström, L., … Hellström-Lindberg, E. (2024). Patient-Specific Measurable Residual Disease Markers Predict Outcome in Patients With Myelodysplastic Syndrome and Related Diseases After Hematopoietic Stem-Cell Transplantation. In Journal of Clinical Oncology (Vol. 42, Issue 12, pp. 1378–1390). https://doi.org/10.1200/JCO.23.01159Opens in a new tab
