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Supplementary information for dissertation "CAR-T cells for Immunotherapy of Cancer"

https://doi.org/10.57804/t9yy-1d15
Supplementary information on the dissertation "CAR T cells for Immunotherapy of Cancer", with the following list of sub-papers: 1. Single-cell RNA analysis reveal subpopulations of CAR T cells correlating with response in lymphoma patients 2. Preclinical evaluation of CAR20(NAP)-T cells for B cell lymphoma 3. Complementary-determining region clustering causes CAR-T cell dysfunction 4. Armed CAR-T cells directed against IL13Rα2 show potent activity against glioblastoma Differentially expressed genes between responders and non-responders (Fc -1.2 ≤ or ≤ 1.2). The dataset was originally published in DiVA and moved to SND in 2024.
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  • SUPPLEMENTARY_INFO_Paper1.pdf
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  • SUPPLEMENTARY_INFO_Paper3.pdf
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  • SUPPLEMENTARY_INFO_Paper4_Table8.txt
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  • SUPPLEMENTARY_INFO_Paper4.pdf
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Citation and access

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Creator/Principal investigator(s):

  • Tina Sarén - Uppsala University

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No

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Method and outcome

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Administrative information

URN:

urn:nbn:se:uu:diva-468713Opens in a new tab

URN:

urn:nbn:se:uu:diva-468834Opens in a new tab

URN:

urn:nbn:se:uu:diva-468835Opens in a new tab

URN:

urn:nbn:se:uu:diva-468712Opens in a new tab

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Obsoletes:

https://nbn-resolving.org/urn:nbn:se:uu:diva-468713Opens in a new tab

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https://nbn-resolving.org/urn:nbn:se:uu:diva-468712Opens in a new tab

Obsoletes:

https://nbn-resolving.org/urn:nbn:se:uu:diva-468834Opens in a new tab

Obsoletes:

https://nbn-resolving.org/urn:nbn:se:uu:diva-468835Opens in a new tab

Publications

Citation:

Sarén, T., Saronio, G., Marti Torrell, P. et al. Complementarity-determining region clustering may cause CAR-T cell dysfunction. Nat Commun 14, 4732 (2023). https://doi.org/10.1038/s41467-023-40303-zOpens in a new tab

Citation:

Sarén, T. 2022. CAR T cells for Immunotherapy of Cancer. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1814. 57 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-1430-3

Citation:

Sarén T, Ramachandran M, Gammelgård G, Lövgren T, Mirabello C, Björklund ÅK, Wikström K, Hashemi J, Freyhult E, Ahlström H, Amini RM, Hagberg H, Loskog A, Enblad G, Essand M. Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients. Clin Cancer Res. 2023 Oct 13;29(20):4139-4152. doi: 10.1158/1078-0432.CCR-23-0178. PMID: 37540566; PMCID: PMC10570681.

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