Data on brain serotonergic activity in Premenstrual Dysphoria
https://doi.org/10.57804/8e1r-pj05
Dataset investigating potential quantitative and qualitative differences in brain serotonergic activity between women with Premenstrual Dysphoria (PMD) and asymptomatic controls.
Positron-emission tomography with the immediate precursor of serotonin, 5-hydroxytryptophan (5-HTP), radiolabelled by 11C in the beta-3 position, was performed in the follicular and luteal phases for 12 women with PMD and 8 control women. Brain radioactivity–a proxym for serotonin precursor uptake and synthesis–was measured in 9 regions of interest (ROIs): the right and left sides of the medial prefrontal cortex, dorsolateral prefrontal cortex, putamen and caudate nucleus, and the single “whole brain”.
The dataset was originally published in DiVA and moved to SND in 2024.
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Contributor(s):
- Ulf Olsson - Swedish University of Agricultural Sciences - Unit of Applied Statistics and Mathematics
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Publications
Publications
Citation:
Eriksson O, Wall A, Olsson U, Marteinsdottir I, Holstad M, Ågren H, et al. (2016) Women with Premenstrual Dysphoria Lack the Seemingly Normal Premenstrual Right-Sided Relative Dominance of 5-HTP-Derived Serotonergic Activity in the Dorsolateral Prefrontal Cortices - A Possible Cause of Disabling Mood Symptoms. PLoS ONE 11(9): e0159538. doi:10.1371/journal.pone.0159538
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