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Effects of early treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) on the bronchoalveolar lavage proteome and oxylipids during Bovine respiratory syncytial virus (BRSV) infection

Effect of NSAIDs on the pulmonary proteome and oxylipids during BRSV infection
https://doi.org/10.5878/5hzt-ps44
Proteins and oxylipids in plasma and bronchoalveolar lavage (BAL), of calves treated against bovine respiratory syncytial virus infection, with meloxicam (MEL, n=5), aspirin (ASA, n=5), or not (CTR, n=5, untreated controls). Proteins and oxylipids were detected by label-free quantitative mass spectrometry-based proteomics and liquid chromatography/tandem mass spectrometry with triple quadrupole mass detectors, respectively. The design and methods of this trial is described in detail in Hägglund et al. 2024. Data files: 2024-08-24_proteomic_oxilipids_BRSV_to_NDS_BAL_oxylipids_pg_ml.tsv: 31 rows × 26 columns 2024-08-24_proteomic_oxilipids_BRSV_to_NDS_BAL_proteins_LFQ.tsv: 797 rows × 32 columns 2024-08-24_proteomic_oxilipids_BRSV_to_NDS_plasma_oxylipids_pg_ml.tsv: 45 rows × 32 columns
Download data and documentation (7 files / 344.25 KiB)

Data files

  • 2024-08-24_proteomic_oxilipids_BRSV_to_NDS_BAL_oxylipids_pg_ml.tsv
    5.86 KiB
  • 2024-08-24_proteomic_oxilipids_BRSV_to_NDS_BAL_proteins_LFQ.tsv
    167.53 KiB
  • 2024-08-24_proteomic_oxilipids_BRSV_to_NDS_plasma_oxylipids_pg_ml.tsv
    13.07 KiB
  • 2024-08-24_proteomic_oxilipids_BRSV_to_NDS.xlsx
    151.87 KiB

Documentation files

  • NDS_Effect_of_NSAIDs_on_the_pulmonary_proteome_and_oxylipids_during_BRSV_infection_BAL_oxylipids.txt
    2.03 KiB
  • NDS_Effect_of_NSAIDs_on_the_pulmonary_proteome_and_oxylipids_during_BRSV_infection_BAL_proteins.txt
    1.97 KiB
  • NDS_Effect_of_NSAIDs_on_the_pulmonary_proteome_and_oxylipids_during_BRSV_infection_plasma_oxylipids.txt
    1.92 KiB

Citation and access

Data access level:

Creator/Principal investigator(s):

Research principal:

Principal's reference number:

  • SLU.klinvet.2024.4.4.IÄ-7

Data contains personal data:

No

Citation:

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Method and outcome

Population:

Calves treated against bovine respiratory syncytial virus infection, with meloxicam (MEL, n=5), aspirin (ASA, n=5), or not (CTR, n=5, untreated controls).

Time method:

Study design:

  • Experimental study

Description of study design:

For a complete description of the experimental design, please see Hägglund et al 2024.

Data format/data structure:

Administrative information

Responsible department/unit:

Department of Clinical Sciences

Ethics Review:

Uppsala - 5.8.18-13628_2021

Funding

Funding agency:

Award number:

2016-01770_Formas

Award title:

Nya behandlingsmetoder för luftvägssjukdom hos nötkreatur

Funding information:

https://www.vr.se/english/swecris.html#/project/2016-01770_Formas

Topic and keywords

Standard för svensk indelning av forskningsämnen 2025:

Keywords:

Publications

Citation:

Hägglund S, Laloy E, Alvarez I, Guo Y, Hallbrink Ågren G, Yazdan Panah H, et al. (2024) Effects of early treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) on the bronchoalveolar lavage proteome and oxylipids during bovine respiratory syncytial virus (BRSV) infection. PLoS ONE 19(11): e0309609.

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Metadata

Version 1
doris
slu
Published:|Updated: