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Data for: Gut microbiota markers in early childhood are linked to farm living, pets in household and allergy

https://doi.org/10.5878/j3eq-7y09
These data underly a study which described longitudinal gut microbiota development during early childhood, and investigated associations with early life exposures and allergy outcomes. The dataset includes variables on: Host factors and early life exposures: sex, parental allergy, farm residence, pet ownership, and breastfeeding Gut microbiota development: presence and population counts of selected bacterial groups at 9 timepoints between 3 days and 18 months of age. These data were obtained using quantitative bacterial culture of fecal samples, targeting key facultative and anaerobic bacteria of the infant gut (exception: samples obtained at 3 days of age were not cultured quantitatively and targeted facultative bacteria only). Allergy at 3 and 8 years of age: clinical diagnosis of allergy (eczema, food allergy, allergic rhinoconjunctivitis or asthma)
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Citation and access

Data access level:

Creator/​Principal investigator(s):

Research principal:

Data contains personal data:

Yes

Type of personal data:

Pseudonymized health data

Code key exists:

Yes

Sensitive personal data:

Yes

Citation:

Language:

Method and outcome

Unit of analysis:

Population:

Children participating in the FARMFLORA birth cohort study. Around half of these children lived on a farm and half in the same rural area. The study followed the children from birth up to 8 years of age.

Time method:

Study design:

  • Cohort study: Prospective
  • Cohort study
  • Observational study

Description of sampling:

The aim of the FARMFLORA study was to map which factors in the farming environment protect against allergy development. The FARMFLORA birth cohort included 65 children of whom 28 lived on dairy farms and 37 lived in a rural area but not on a farm in the Västra Götaland region in South-West Sweden. Recruitment to the cohort occurred between September 2005 and March 2008, by approaching pregnant women at maternity clinics in the study area. The children included were born at ≥38 weeks of gestation.

Time period(s) investigated:

Variables:

237

Number of individuals/​objects:

65

Data format/​data structure:

Data collection

Description of the mode of collection:

Fecal samples were collected from children on nine occasions from 3 days to 18 months of age. The samples were subjected to quantative bacterial culture, and key bacteria of the infant gut were identified and quantified (exception: samples obtained at 3 days of age were not cultured quantitatively). Data on farm residence, pets in the household and parental allergy were registered upon inclusion Data on breastfeeding was registered by the parents and collected by telephone interviews Allergy was diagnosed by clinical evaluation of children using set diagnostic criteria for atopic eczema, food allergy, asthma or allergic rhinoconjunctivitis by experienced pediatricians at three and eight years of age

Time period(s) for data collection:

2005-09 - 2015-05

Geographic coverage

Geographic location:

Administrative information

Responsible department/​unit:

Institute of Biomedicine, Department of Infectious Diseases; Institute of Clinical Sciences; Institute of Medicine

Contributor(s):

Ethical Review

Reviewer:

  • Gothenburg Ethical Review Board

Registration number:

363-05

Reviewer:

  • Gothenburg Ethical Review Board

Registration number:

674-14

Funding

Funding agency:

  • Region Västra Götaland (agreement concerning medical research and education – ALF)

Award number:

ALFGBG966243

Funding agency:

  • Region Västra Götaland (agreement concerning medical research and education – ALF)

Award number:

ALFGBG720181

Funding agency:

  • Swedish Medical Research Council

Award number:

K98-06X-12612-01A

Funding agency:

  • Health & Medical Care Committee of the Region Västra Götaland (Regional Research & Development funds Västra Götaland region)

Award number:

VGFOUREG-12007

Topic and keywords

CESSDA topic classification:

Swedish Standard Classification of Research Subjects 2025:

Keywords:

Publications

Citation:

Ljung A, Gio-Batta M, Hesselmar B, Imberg H, Rabe H, et al. (2024) Gut microbiota markers in early childhood are linked to farm living, pets in household and allergy. PLOS ONE 19(11): e0313078. https://doi.org/10.1371/journal.pone.0313078

Metadata

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