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Data for: Major gut microbiota perturbations in firstborn infants compared to those with older siblings soon after delivery

https://doi.org/10.5878/ea19-6s81
These data underly a study which investigated the influence of early life exposures on longitudinal gut microbiota development during early childhood. The dataset includes variables on: Host factors and early life exposures: sex, delivery mode (caesarian section or vaginal), older siblings (yes or no), exposure to antibiotics during delivery (intrapartum antibiotics, yes or no) and breastfeeding. Gut microbiota development: presence and population counts of selected bacterial groups at 9 timepoints between 3 days and 18 months of age. These data were obtained using quantitative bacterial culture of fecal samples, targeting key facultative and anaerobic bacteria of the infant gut (exception: samples obtained at 3 days of age were not cultured quantitatively and targeted facultative bacteria only).
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Citation and access

Data access level:

Creator/​Principal investigator(s):

Research principal:

Data contains personal data:

Yes

Type of personal data:

Pseudonymized health data

Code key exists:

Yes

Sensitive personal data:

Yes

Citation:

Language:

Method and outcome

Population:

Children participating in the FARMFLORA birth cohort study. Around half of these children lived on a farm and half lived in the same rural area but not on a farm.

Study design:

  • Cohort study
  • Observational study

Description of sampling:

The FARMFLORA birth cohort included 65 children of whom 28 lived on dairy farms and 37 lived in the same rural area but not on a farm in the Västra Götaland region in South-West Sweden. Recruitment to the cohort occurred between September 2005 and March 2008, by approaching pregnant women at maternity clinics in the study area. The children included were born at ≥38 weeks of gestation.

Time period(s) investigated:

Variables:

235

Number of individuals/​objects:

65

Data format/​data structure:

Data collection Biological tests

Mode of collection:

Biological tests

Description of the mode of collection:

Fecal samples were collected from children on nine occasions from 3 days to 18 months of age. The samples were subjected to quantative bacterial culture, and key bacteria of the infant gut were identified and quantified (exception: samples obtained at 3 days of age were not cultured quantitatively). Data on delivery mode (caesarian section or vaginal) and exposure to antibiotics during delivery (intrapartum antibiotics) were retrieved from hospital records. Data on older siblings were registered on inclusion. Data on breastfeeding was registered by the parents and collected at 6, 12 and 18 months of age.

Time period(s) for data collection:

2005-09 - 2009-09

Data collector:

Sample size:

65

Geographic coverage

Geographic location:

Administrative information

Responsible department/​unit:

Institute of Biomedicine, Department of Infectious Diseases; Institute of Clinical Sciences; Institute of Medicine

Contributor(s):

Ethical Review

Reviewer:

  • Gothenburg Ethical Review Board

Registration number:

363-05

Reviewer:

  • Gothenburg Ethical Review Board

Registration number:

674-14

Funding

Funding agency:

Award number:

ALFGBG966243

Funding agency:

Award number:

ALFGBG720181

Funding agency:

Award number:

K98-06X-12612-01A

Funding agency:

Award number:

VGFOUREG-12007

Topic and keywords

CESSDA topic classification:

Swedish Standard Classification of Research Subjects 2025:

Keywords:

Relations

Related research data:

Publications

Citation:

Ljung A, Gio-Batta M, Hesselmar B, Rabe H, Nowrouzian FL, Johansen S, Wold AE, Adlerberth I. Major gut microbiota perturbations in firstborn infants compared to those with older siblings soon after delivery. BMC Pediatrics 25, 780 (2025). https://doi.org/10.1186/s12887-025-06015-7

Metadata

Version 1
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Version 1 published: