Data for: "Spatial evidence for carcinoma in situ (CIS) as an entity in human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (TSCC)"
Citation and access
Citation and access
Data access level:
Creator/Principal investigator(s):
Research principal:
Data contains personal data:
Yes
Type of personal data:
health data
Code key exists:
Yes
Sensitive personal data:
Yes
Citation:
Language:
Method and outcome
Method and outcome
Unit of analysis:
Population:
Patients with HPV-associated oropharyngeal cancer, having histopathological findings
Time method:
Study design:
- Observational study
Description of sampling:
All HPV DNA positive and p16 over-expressing tonsillar carcinoma cases (HE-slides) harboring normal epithelium, epithelium showing characteristics of HGD/CIS and invasive carcinoma were selected from a total cohort of 44 patients diagnosed with the disease during 2023. In total three such cases were identified. In addition, three consecutive cases of HPV-independent oral squamous cell carcinomas (OSCC) from 2023 were selected from the same registry and two anonymized HPV-associated cervical squamous cell carcinoma (CxCa) cases were also obtained for controls.
Number of individuals/objects:
5
Samples/material - Existing from scientific collection/biobank
Samples/material - Existing from scientific collection/biobank
Name:
Type(s) of sample:
Data collection - Other
Data collection - Other
Mode of collection:
Other
Description of the mode of collection:
spatial transcriptomics
Time period(s) for data collection:
2023-01-01 - 2023-12-31
Administrative information
Administrative information
Responsible department/unit:
Department of Oncology-Pathology [K7]
Other research principals:
Ethics Review 1:
Swedish Ethical Review Authority - 2023-01911-01
Ethics Review 2:
Swedish Ethical Review Authority - 2025-01516-02
Funding
Funding
Funding agency:
- Karolinska Institutet
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Award number:
2025-00345_KI
