Data for "Pancreatic α-cell dysfunction associated with equine insulin dysregulation", published in Equine Veterinary Journal (EVJ)
https://doi.org/10.5878/et2s-3r68
Data in this file were derived from a cross-sectional experimental study involving healthy horses (NIR; n = 19) and horses previously diagnosed with insulin dysregulation (ID; n = 19). All horses underwent a 180-minute, seven-sample oral sugar test. Primary endpoints included group comparison (ID vs NIR) of pancreatic α-cell indices (Fasting glucagon and AUC glucagon). The data file consists of 17 columns and 38 rows.
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Citation and access
Citation and access
Access level:
Creator/Principal investigator(s):
Research principal:
Principal's reference number:
- SLU.klinvet.2026.4.2.IÄ-8
Data contains personal data:
No
Citation:
Language:
Method and outcome
Method and outcome
Population:
19 healthy horses and 19 horses previously diagnosed with insulin dysregulation.
Time method:
Study design:
- Experimental study
Description of study design:
All horses underwent a 180-minute, seven-sample oral sugar test. Blood samples were analysed for concentrations of glucose, insulin and glucagon.
Sampling procedure:
Description of sampling:
Purposive sampling. Horses and ponies were enrolled in the study based on results from a single-sample oral sugar test performed in the field, using insulin concentrations > 45 µIU/mL measured in blood 60 to 90 min after oral sugar administration as a diagnostic cut-off for ID.
Variables:
17
Number of individuals/objects:
38
Data format/data structure:
Data collection - Experiment
Data collection - Experiment
Mode of collection:
Experiment
Description of the mode of collection:
Oral sugar test
Data collector:
- Swedish University of Agricultural Sciences
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ROR
Source of the data:
- Biological samples
Geographic coverage
Geographic coverage
Geographic location:
Administrative information
Administrative information
Responsible department/unit:
Department of Clinical Sciences
Contributor(s):
- Johan Bröjer – Swedish University of Agricultural Sciences - Department of Clinical Sciences
- Emma Strage – Swedish University of Agricultural Sciences - Department of Clinical Sciences
- Josefin Söder – Swedish University of Agricultural Sciences - Department of Clinical Sciences
Ethical Review
Ethical Review
Reviewer:
- Swedish Ethical Review Authority
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ROR
Registration number:
C19/14, C269/12
Ethical review information:
The study (C19/14, C269/12) was approved by the Ethical Committee for Animal Experiments, Uppsala, Sweden.
Funding
Funding
Funding agency:
- Swedish-Norwegian Foundation for Equine Research
Award number:
(H-18-47-390
Award title:
The role of glucagon in the pathogenesis of hyperinsulinemia induced laminitis of the horse
Topic and keywords
Topic and keywords
Swedish Standard Classification of Research Subjects 2025:
Publications
Publications
Citation:
Sanna Lindåse, Emma Strage, Josefin Söder, Johan Bröjer. Pancreatic α-cell dysfunction associated with equine insulin dysregulation. Accepted for publication in Equine Veterinary Journal, 2026.
