Mutational Signature Contribution of Matched Primary and Recurrent Breast Tumors

Mutational signature contribution table reports COSMIC mutational signatures (v2; https://cancer.sanger.ac.uk/signatures/signatures_v2Opens in a new tab) for matched primary and locally recurrent tumors (n = 27 + 27). "SUBSTITUTION.TABLE" contains the number of nucleotide substitutions (type by sample). "MUT.SIG.contribution" reorts the fractional contribution of all 30 COSMIC signatures in each samples. "MUT.SIG.contrib.DELTAOpens in a new tab" reports pair-wise contribution difference (DELTA = contribution.recurrence - contribution.primary) for paired samples. This dataset was used for Figure 2 in the following manuscript: "Proteogenomics decodes the evolution of human ipsilateral breast cancer". De Marchi T, Pyl PT, Sjöström M, Reinsbach SE, DiLorenzo S, Nystedt B, Tran L, Pekar G, Wärnberg F, Fredriksson I, Malmström P, Fernö M, Malmström L, Malmström J, Nimèus E. accepted for publication