The genomic landscape of relapsed infant and childhood KMT2A-rearranged acuteleukemia
https://doi.org/10.17044/SCILIFELAB.26064754
This dataset includes whole genome and whole exome sequencing of diagnostic, germline, and relapse samples of 21 infants and 12 children with relapsed ALL (n=21) or AML (n=12), and targeted deep sequencing of 258 samples taken during treatment for 30 infants or children with ALL or AML. All patients had an underlying rearrangement of the KMT2A gene
Whole genome and exome sequencing was performed using Illumina TruSeq Nano protocol. Targeted sequencing libraries was prepared using Nextera XT DNA Sample Preparation Kit (Illumina) and sequenced on the Illumina MiSeq.
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https://doi.org/10.17044/SCILIFELAB.26064754
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Creator/Principal investigator(s):
- Anna Hagström Andersson
- Louise Ahlgren
- Helena Sturesson
- Guangchun Song
- Michael P. Walsh
- Anders Castor
- Cornelis Jan Pronk
- Huanbin Zhao
- Maud Maillard
- Birgitte Lausen
- Pauline Schneider
- Katja Pokrovskaja-Tamm
- Jonas Abrahamsson
- Linda Fogelstrand
- Pablo Menendez
- Rob Pieters
- Jun J. Yang
- Jinghui Zhang
- Karin Lindkvist-Petersson
- Ronald W. Stam
- Jing Ma
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Administrative information
Administrative information
Funding
Funding
Funding agency:
- Swedish Research Council
Opens a new window at ror.org.
ROR
Award number:
2019-01446_VR
Award title:
The molecular pathogenesis of KMT2A-rearranged leukemia from infancy to adulthood and the clinical impact of tumor heterogeneity
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Topic and keywords
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