MISS-cohort, Melanoma in Southern Sweden
The MISS cohort started in 1990 when 40 000 women between 26 and 65 in Skåne were randomly selected to participate in an interview about the risk factors for malignant melanoma and breast cancer. 29 508 (approximately 74%) of women surveyed chose to participate. None of the women had a history of cancer. The interviews were conducted between 1990 and 1992 and the questions concerned, among other things, the time for the woman's first menstruation, number of pregnancies, age at entry into menopause, contraception, alcohol, smoking, sun exposure and constitutional factors. The cohort was interviewed one more time in year 2000 and again 2011. Re-interviews are scheduled for every ten years. During 2011 to 2013 DNA was collected from the cohort through saliva. Follow-up of morbidity and mortality are made annually through the national registry.
Purpose:
The aim of this study was to create a prospective population-based cohort of women from Southern Sweden with information regarding environmental and genetic factors.
Contact for data - Christian Ingvar
Opens in a new tabchristian.ingvar@med.lu.se
Documentation files
Documentation files
Citation and access
Citation and access
Data access level:
Creator/Principal investigator(s):
- Håkan Olsson - Lund University - Faculty of Medicine, The Division of Oncology and Pathology
- Christian Ingvar - Lund University - Faculty of Medicine, Surgery
Research principal:
Data contains personal data:
Yes
Sensitive personal data:
Yes
Citation:
Method and outcome
Method and outcome
Unit of analysis:
Population:
Women between 25 and 65 years, living in Southern Sweden.
Time method:
Sampling procedure:
Time period(s) investigated:
Description of the response rate/participation rate:
Enkäten: 29 508 individer, 74% svarsfrekvens DNA-prov: 15 000 individer. ca 50% svarsfrekvens
Data format/data structure:
Data collections - 4 collections
Data collections - 4 collections
Data collection - Self-administered questionnaire
Data collection - Self-administered questionnaire
Mode of collection:
Self-administered questionnaire
Time period(s) for data collection:
1990 - 1992
Source of the data:
- Population group
- Biological samples
Data collection - Self-administered questionnaire
Data collection - Self-administered questionnaire
Mode of collection:
Self-administered questionnaire
Time period(s) for data collection:
2000 - 2000
Source of the data:
- Population group
- Biological samples
Data collection - Self-administered questionnaire
Data collection - Self-administered questionnaire
Mode of collection:
Self-administered questionnaire
Time period(s) for data collection:
2011 - 2011
Source of the data:
- Population group
- Biological samples
Data collection - Physical measurements and tests
Data collection - Physical measurements and tests
Mode of collection:
Physical measurements and tests
Description of the mode of collection:
DNA från saliv har samlats in från >50% av kohorten.
Time period(s) for data collection:
2011 - 2013
Source of the data:
- Population group
- Biological samples
Geographic coverage
Geographic coverage
Geographic description:
Southern Sweden
Administrative information
Administrative information
Responsible department/unit:
Faculty of Medicine
Topic and keywords
Topic and keywords
CESSDA Topic Classification:
Standard för svensk indelning av forskningsämnen 2025:
Publications
Publications
Citation:
Lindqvist, P. G., Epstein, E., Nielsen, K., Landin-Olsson, M., Ingvar, C., & Olsson, H. (n.d.). Avoidance of sun exposure as a risk factor for major causes of death : A competing risk analysis of the Melanoma in Southern Sweden cohort. In Journal of Internal Medicine (Vol. 280, Issue 4, pp. 375–387). https://doi.org/10.1111/joim.12496Opens in a new tab
Citation:
Olsson, H., & Bladström, A. (2002). A cohort study of reproductive factors and family history of breast cancer in southern Sweden. In Breast Cancer Research and Treatment (Vol. 76, Issue 3, pp. 203–209). https://doi.org/10.1023/A:1020807619092Opens in a new tab
Citation:
Lindqvist, P. G., Epstein, E., Landin-Olsson, M., Ingvar, C., Nielsen, K., Stenbeck, M., & Olsson, H. (n.d.). Avoidance of sun exposure is a risk factor for all-cause mortality: results from the Melanoma in Southern Sweden cohort. In Journal of Internal Medicine (Vol. 276, Issue 1, pp. 77–86). https://doi.org/10.1111/joim.12251Opens in a new tab
Citation:
Epstein, E., Lindqvist, P., & Olsson, H. (2009). A population-based cohort study on the use of hormone treatment and endometrial cancer in southern Sweden. In International Journal of Cancer (Vol. 125, pp. 421–425). https://doi.org/10.1002/ijc.24284Opens in a new tab
Citation:
Lindqvist, P. G., Olsson, H., & Landin-Olsson, M. (2010). Are active sun exposure habits related to lowering risk of type 2 diabetes mellitus in women, a prospective cohort study? In Diabetes Research and Clinical Practice (Vol. 90, Issue 1, pp. 109–114). https://doi.org/10.1016/j.diabres.2010.06.007Opens in a new tab
Citation:
Lindqvist, P. G., Epstein, E., Landin-Olsson, M., Åkerlund, M., & Olsson, H. (n.d.). Women with fair phenotypes seem to confer a survival advantage in a low UV milieu. A nested matched case control study. In PLoS ONE (No. e0228582; Vol. 15, Issue 1). https://doi.org/10.1371/journal.pone.0228582Opens in a new tab
Citation:
Lindqvist, P., Landin-Olsson, M., & Olsson, H. (n.d.). Low sun exposure habits is associated with a dose-dependent increased risk of hypertension: a report from the large MISS cohort. In Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology (Vol. 20, Issue 2, pp. 285–292). https://doi.org/10.1007/s43630-021-00017-xOpens in a new tab
Citation:
Lindqvist, P. G., Epstein, E., & Olsson, H. (2009). Does an active sun exposure habit lower the risk of venous thrombotic events? A D-lightful hypothesis. In Journal of Thrombosis and Haemostasis (Vol. 7, Issue 4, pp. 605–610). https://doi.org/10.1111/j.1538-7836.2009.03312.xOpens in a new tab
Citation:
Epstein, E., Lindqvist, P., Geppert, B., & Olsson, H. (n.d.). A population-based cohort study on sun habits and endometrial cancer. In British Journal of Cancer (Vol. 101, pp. 537–540). https://doi.org/10.1038/sj.bjc.6605149Opens in a new tab
