Uppsala Family Study
The Uppsala Family Study was initiated in 2000-2001 when 602 families (mothers, fathers, two consecutive siblings age 5-14 years) living in Uppsala were examined with focus on anthropometry and blood pressure. Blood samples were taken for biochemical and genetic analyses. Parents answered medical and lifestyle questionnaires and filled in a medical questionnaire for each child. Families were randomly selected from a sampling frame where children were selected from the Medical Birth Registry based on them being consecutive singleton full siblings where both had high or low birth weight or where they were discordant in birth weight. In 2010-2014, all families were invited for a second round of examinations; 513 parents (age 39-70 years) and 466 children (age 14-23 years) attended. This second round of examinations included largely the same procedures as the first round; anthropometry, blood pressure, blood sampling, and all participants answered a detailed questionnaire on medical history, lifestyle habits including physical activity, education and living conditions. Additionally, participants underwent DXA-scans to determine bone, fat and lean muscle mass. Additional information available includes pregnancy specific information from the Medical Birth Registry (children), parental birth data and longitudinal information on children's growth from child and school health records. The family design of the Uppsala Family Study provides good opportunities to examine the contribution of maternal and paternal factors on, for instance, the association between birth weight and later outcomes in the offspring.
Purpose:
To study effects of birth weight and growth on cardiovascular, metabolic and bone-related outcomes using a family design.
Contact for data - Liisa Byberg
Opens in a new tabliisa.byberg@surgsci.uu.se
Citation and access
Citation and access
Data access level:
Creator/Principal investigator(s):
- Liisa Byberg - Uppsala University - Department of Surgical Sciences
Research principal:
Citation:
Method and outcome
Method and outcome
Unit of analysis:
Time method:
Sampling procedure:
Data format/data structure:
Data collections - 4 collections
Data collections - 4 collections
Data collection - Physical measurements and tests
Data collection - Physical measurements and tests
Mode of collection:
Physical measurements and tests
Time period(s) for data collection:
2000 - 2001
Source of the data:
- Population group
- Biological samples
Data collection - Self-administered questionnaire
Data collection - Self-administered questionnaire
Mode of collection:
Self-administered questionnaire
Time period(s) for data collection:
2000 - 2001
Source of the data:
- Population group
- Biological samples
Data collection - Self-administered questionnaire
Data collection - Self-administered questionnaire
Mode of collection:
Self-administered questionnaire
Time period(s) for data collection:
2010 - 2014
Source of the data:
- Population group
- Biological samples
Data collection - Physical measurements and tests
Data collection - Physical measurements and tests
Mode of collection:
Physical measurements and tests
Time period(s) for data collection:
2010 - 2014
Source of the data:
- Population group
- Biological samples
Administrative information
Administrative information
Responsible department/unit:
Department of Surgical Sciences
Topic and keywords
Topic and keywords
CESSDA Topic Classification:
Standard för svensk indelning av forskningsämnen 2025:
Publications
Publications
Citation:
Silverwook RJ, De Stavola BL, Cole TJ, Leon DA. BMI peak in infancy as a predictor for later BMI in the Uppsala Family Study. Int J Obes 2009;33(8):929-37. doi: 10.1038/ijo.2009.108
Citation:
Khanolkar AR, Byberg L, Koupil I. Parental influences on cardiovascular risk factors in Swedish children aged 5-14 years. Eur J Public Health 2012;22(6):840-7. doi: 10.1093/eurpub/ckr180
Citation:
Leon DA, Koupil I, Mann V, Tuvemo T, Lindmark G, Mohsen R, Byberg L, Lithell H. Fetal, developmental, and parental influences on childhood systolic blood pressure in 600 sib pairs: the Uppsala Family Study. Circulation 2005;112(22):3478-85. doi: 10.1161/CIRCULATIONAHA.104.497610
Citation:
Weedon MN, Frayling TM, Shields B, Knight B, Turner T, Metcalf BS, Voss L, Wilkin TJ, McCarthy A, Ben-Shlomo Y, Davey Smith G, Ring S, Jones R, Golding J, Byberg L, Mann V, Axelsson T, Syvänen AC, Leon D, Hattersley AT. Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene. Diabetes 2005;54(2):576-81. doi: 10.2337/diabetes.54.2.576
Citation:
Nitsch D, Sandling JK, Byberg L, Larsson A, Tuvemo T, Syvänen AC, Koupil I, Leon DA. Fetal, developmental and parental influences on cystatin C in childhood: the Uppsala Family Study. Am J Kidney Dis 2011;57(6):863-72. doi: 10.1053/j.ajkd.2010.12.025
Citation:
Mann V, De Stavola BL, Leon DA. Separating within and between effects in family studies: an application to the study of blood pressure in children. Stat Med 2004; 23(17):2745-56.
Citation:
Koupil I. The Uppsala studies on developmental origins of health and disease. J Intern Med 2007;261(5):426-36.
