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Data showing how Repeated Lumbar Punctures within 3 days may affect CSF Biomarker Levels

https://doi.org/10.5878/14p1-3w07
As an extension of a study on the relationship between sleep deprivation and cerebrospinal fluid (CSF) biomarkers for Alzheimer’s disease, we performed two Lumbar punctures (LPs) within three days in 13 healthy volunteers (N=13). Our aim was to investigate CSF biomarker dynamics in relation to sleep deprivation. An unexpected sharp rise in biomarker concentrations in the second sample made us consider an artifact and we therefore repeated the experiment, but without sleep restriction, in four additional individuals (N=4). A similar rise in biomarker levels were evident, suggesting an inherent methodological problem with repeated LPs. Experiment 1: Repeated lumbar punctures within 3 days without sleep intervention. Participants with controled normal sleep. Biomarker concentrations from each individual lumbar puncture. Experiment 2: After sleep deprivation and 3 days later, after recovery sleep. Biomarker concentrations from each individual lumbar puncture. First puncture immediately after sleep deprivation. Second puncture three days later, after recovery sleep.
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Data files

  • Recovery sleep LP biomarker data.xlsx
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  • Repeated LP biomarker data.xlsx
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Documentation files

  • readme.txt
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Citation and access

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Creator/Principal investigator(s):

Research principal:

Data contains personal data:

No

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Method and outcome

Unit of analysis:

Population:

Healthy volunteers

Study design:

  • Cross-over
  • Randomised controlled trial (RCT)
  • Experimental study

Description of study design:

Randomized crossover

Sampling procedure:

Description of sampling:

13 healthy volunteers recruited by posters on university campus. 20-40 years of age with no sleep disturbances. Body-Mass-index (BMI) < 30 kg/m2. No continual use of medication or relevant chronic diseases. Self-reported normal bedtime < 00.00, regular morning awakening hours 06.00-09.00, habitual sleep duration of between 6.5-8.5 hours and absence of sleep disturbances (such as chronic insomnia/daytime sleepiness/narcolepsy). Epworth Sleepiness Scale (ESS) score < 11. Experiment then repeated with 4 additional individuals

Time period(s) investigated:

Variables:

8

Number of individuals/objects:

17

Data format/data structure:

Administrative information

Responsible department/unit:

Institute of Neuroscience and Physiology

Ethics Review:

Gothenburg - 823-14

Topic and keywords

Standard för svensk indelning av forskningsämnen 2025:

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Relations

Obsoletes:

https://doi.org/10.5878/cavp-eh78Opens in a new tab

Publications

Citation:

Olsson M, Arlig J, Hedner J, Blennow K, Zetterberg H. Sleep deprivation and cerebrospinal fluid biomarkers for Alzheimer's disease. Sleep. 2018;41(5). https://doi.org/10.1093/sleep/zsy025Opens in a new tab

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Citation:

Olsson, M., Ärlig, J., Hedner, J. et al. Repeated lumbar punctures within 3 days may affect CSF biomarker levels. Fluids Barriers CNS 16, 37 (2019) doi:10.1186/s12987-019-0157-2

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Metadata

Versions

Version:

2

DOI:

https://doi.org/10.5878/14p1-3w07Opens in a new tab

  • Data merged:

    Data from: " Repeated lumbar punctures within 3 days may affect CSF biomarker levels - Repeated lumbar punctures within 3 days without sleep intervention" (version 1.0, DOI 10.5878/tpbk-k885); " Repeated lumbar punctures within 3 days may affect CSF biomarker levels - Repeated lumbar punctures. After sleep deprivation and 3 days later, after recovery sleep" (version 1.0, DOI 10.5878/cavp-eh78).

Published:

Version:

1.0

DOI:

https://doi.org/10.5878/tpbk-k885Opens in a new tab

Published:

doris
gu_en
Published: