RNA-sequencing data from: The cellular state space of AML unveils novel NPM1 subtypes with distinct clinical outcomes and immune evasion properties, and: The complement receptor C3AR constitutes a novel therapeutic target in NPM1-mutated AML

This dataset contains bulk RNA-sequencing (RNA-seq) gene expression data from from 120 AML-samples from the subtypes NPM1 (n=33), AML-MR (n=30), TP53 (n=18), PML::RARA (n=8), CBFB::MYH11 (n=8), AML without class defining mutations (n=8), RUNX1::RUNX1T1 (n=3), KMT2A fusion genes (n=3), AML meeting the criteria for two subtypes (n=2), DEK-NUP214 (n=2), GATA2::MECOM (n=1), and bialleleic CEBPA mutation (n=1). The single cell libraries were constructed from bone marrow (n=102) or peripheral blood (n=18) using the TruSeq RNA Library Prep Kit v2 (Illumina) and sequenced on a NextSeq 500. Reads were aligned against human reference genome hg19 and read counts were determined using RSEM v1.2.30 (https://github.com/deweylab/RSEMÖppnas i en ny tabb) with gencode v19 as gene reference. Data is available as fpkm-values as determined by RSEM. Raw sequencing reads (fastq) are available at the European Genome-Phenome Archive (EGA) under accession ID EGAD50000001576: https://ega-archive.org/datasets/EGAD50000001576Öppnas i en ny tabb.