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  • This version has been withdrawn and the data are no longer available from Researchdata.se. Please note that there may be a newer version available. Withdrawual due to duplication of this record by https://doi.org/10.48360/jcps-gw67, previously published on DiVA but moved to DORIS in 2024.

Data for: Proteomics reveal biomarkers for diagnosis, disease activity and long-term disability outcomes in multiple sclerosis

The concentration of 1463 proteins were measured using the Olink Explore platform which uses Proximity Extension Assay (PEA) technology. The proteins are preselected from four Olink panels: Explore 384 Cardiometabolic, Explore 384 Inflammation, Explore 384 Neurology, and Explore 384 Oncology. The protein concentrations are given as Olink’s relative protein quantification unit on log2 scale: Normalized Protein Expression (NPX). The NPX values were intensity normalized by Olink. Protein levels were measured in cerebrospinal fluid samples (n = 186) and plasma samples (n = 165) from persons with multiple sclerosis and healthy controls.

Citation and access

Data access level:

Creator/Principal investigator(s):

Research principal:

Data contains personal data:

Yes

Type of personal data:

The data is pseudonymised and contains information if samples are from persons with MS or healthy controls, and the age and sex of these persons.

Code key exists:

Yes

Sensitive personal data:

Yes

Citation:

Language:

Method and outcome

Population:

Cerebrospinal fluid (CSF) samples and plasma samples were taken from 92 persons with CIS or RRMS at Linköping University Hospital, Sweden and 51 persons with CIS or RRMS at the Karolinska University Hospital, Sweden. Everyone fulfilled the revised McDonald criteria from 2010 and 2017 for CIS or Multiple sclerosis (MS). Age-matched healthy controls (HC) were recruited from healthy blood donors (23 at the Linköping University hospital and 20 at the Karolinska University Hospital).

Time method:

Study design:

  • Observational study
  • Case-control study

Data format/data structure:

Administrative information

Other research principals:

DOI:

10.48360/jcps-gw67Opens in a new tab

Ethics Review 1:

Linköping - 2017/288-31

Ethics Review 2:

Linköping - 2016/305-32

Ethics Review 3:

Stockholm - 2022-03650-02

Ethics Review 4:

Linköping - 2013/155-32

Ethics Review 5:

Linköping - 2016/304-32

Ethics Review 6:

Linköping - 2014/311-31

Funding

Funding agency:

  • European Union's Marie Sklodowska-Curie

Funding agency:

  • Swedish Brain Foundation

Funding agency:

  • Swedish Foundation for Strategic Research

Funding agency:

  • Knut and Alice Wallenberg Foundation

Funding agency:

  • Margareth AF Ugglas Foundation

Funding agency:

  • Swedish Research Council

Funding agency:

  • Swedish Knowledge Foundation

Funding agency:

  • Medical Research Council of Southeast Sweden

Funding agency:

  • NEURO Sweden

Funding agency:

  • ALF grants

Funding agency:

  • Region Östergötland

Funding agency:

  • Swedish Foundation for MS Research

Topic and keywords

CESSDA Topic Classification:

Standard för svensk indelning av forskningsämnen 2025:

Keywords:

Metadata

Version 1
doris
Linköping University
Published:|Updated: