Intestinal barrier function in the colon of irritable bowel syndrome patients and healthy subjects pre- and post-butyrate exposure in vivo
https://doi.org/10.60689/jxc0-3238
The dataset comprises information (age, sex, irritable bowel syndrome (IBS)-subtype and medical information) about 17 IBS patients and 17 healthy subjects and their gastrointestinal problems assessed by GSRS-IBS questionnaires. Additionally, it includes data about the intestinal permeability (passage of intestinal permeability markers fluorescein isothiocyanate (FITC)-dextran and horseradish peroxidase (HRP), and transepithelial resistance measured by Ussing chamber experiments) and ion transport (short circuit current measured by Ussing chamber experiments) of colonic biopsies collected from these 34 study participants pre- and post-exposure to butyrate in vivo.
Citation and access
Citation and access
Data access level:
Creator/Principal investigator(s):
Research principal:
Data contains personal data:
Yes
Type of personal data:
Health related personal data
Code key exists:
Yes
Sensitive personal data:
Yes
Citation:
Language:
Method and outcome
Method and outcome
Unit of analysis:
Population:
Healthy subjects and IBS patients
Time method:
Study design:
- Preclinical study
Description of study design:
Experimental design comparing IBS patients and healthy controls. In both groups intestinal permeability was measured in colonic biopsies collected in the ascending colon to compare intestinal barrier function before and after in vivo exposure to the short-chain fatty acid butyrate.
Sampling procedure:
Time period(s) investigated:
Variables:
42
Number of individuals/objects:
34
Geographic coverage
Geographic coverage
Geographic location:
Administrative information
Administrative information
Responsible department/unit:
Nutrition-Gut-Brain Interactions Research Centre, School of Medical Sciences
Ethics Review:
Central Ethical Review Board - Dnr 2016/464
Funding
Funding
Funding agency:
- Swedish Research Council
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Award number:
2017-02694
Funding agency:
- EFSD/Novo Nordisk Programme 2017
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Funding agency:
- Lantmännen Research Foundation
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Award number:
2019F010
Topic and keywords
Topic and keywords
CESSDA Topic Classification:
Standard för svensk indelning av forskningsämnen 2025:
Publications
Publications
Citation:
Scharf, M. W., Forsgård, R. A., Prado, S. B. R., Ganda Mall, J. P., Repsilber, D., Brummer, R. J., Marques, T. M., & Wall, R. (2025). Acute effects of butyrate on intestinal permeability in patients with irritable bowel syndrome assessed by a novel colonoscopy research model. In Gut microbes (No. 2545414; Vol. 17, Issue 1). https://doi.org/10.1080/19490976.2025.2545414Opens in a new tab
Citation:
Tabat, M. W., Marques, T. M., Markgren, M., Löfvendahl, L., Brummer, R. J., & Wall, R. (n.d.). Acute Effects of Butyrate on Induced Hyperpermeability and Tight Junction Protein Expression in Human Colonic Tissues. In Biomolecules (No. E766; Vol. 10, Issue 5). https://doi.org/10.3390/biom10050766Opens in a new tab
Metadata
Metadata
Version 1
Örebro University