The cohort of 60-year-old men and women
The cohort of 60-year old men and women consists of every third man and woman residing in Stockholm county, who during one year (1997 01 07 - 1998 0630) reached the age of 60, and who subsequently was invited to a careful health control, including blood sampling, and completion of a questionnaire, etc (response rate 78 %). Blood samples and DNA were stored in -80 ?C freezers (4 freezers) both at Karolinska Hospital and the Karolinska Institutet. DNA has been extracted on all subjects and 4232 individuals participated at the health check-up. The predictive role of different risk exposures/biomarkers for cardiovascular diseases (CVD) is assessed through annual matching against available national registers. So far 408 incident CVD cases have been registered (up to 2010, on average 12 years of follow up). About 35 international original articles have been generated from the database. Analyses of baseline data indicate that a variety of metabolic disturbances go unrecognized in this age group, many of which are attributed to low levels of physical exercise and bad life-style habits. Through analyses of incident CVD events using nested case-control designs two novel biomarkers have been identified; 1) Anti-PC (phosphorylcholine) a natural IgM antibody of which low levels reflect disturbed immunological defense mechanisms of the vascular wall and 2) CD 93 of which low levels are related to an increased risk for CVD. Novel potential pathways for CVD are currently investigated through determinations of miRNAs in a nested sample of incident myocardial infarctions and controls through collaboration with the University of Milan, Italy. The running of genome-wide analyses (GWAs) is planned. In addition, particular emphasis will be put on evaluating novel inflammatory biomarkers (immunological antibodies like Ox Cardiolipin, PCSK9 etc.) by multiplex techniques such as the Meso Scale platform.
Purpose:
To assess the predictive role of different risk exposures/biomarkers for cardiovascular diseases (CVD).
Contact for data - Ulf de Faire
Opens in a new tabulf.defaire@ki.se
Citation and access
Citation and access
Data access level:
Creator/Principal investigator(s):
- Ulf de Faire - Karolinska Institutet - Institute of Environmental Medicine
Research principal:
Citation:
Method and outcome
Method and outcome
Unit of analysis:
Population:
2193 women and 2039 men, living in Stockholm county and 60 years of age when included.
Sampling procedure:
Description of sampling:
Annual match to national registers to obtain information about death and inpatient occasions for cardiovascular diseases
Time period(s) investigated:
Number of individuals/objects:
4232
Response rate/participation rate:
78%
Data format/data structure:
Data collection - Physical measurements and tests
Data collection - Physical measurements and tests
Mode of collection:
Physical measurements and tests
Time period(s) for data collection:
1997-01-07 - 1998-06-30
Source of the data:
- Registers/Records/Accounts: Medical/Clinical
- Population group
- Biological samples
- Registers/Records/Accounts
Data collection - Self-administered questionnaire: Paper
Data collection - Self-administered questionnaire: Paper
Mode of collection:
Self-administered questionnaire: Paper
Time period(s) for data collection:
1997-01-07 - 1998-06-30
Source of the data:
- Registers/Records/Accounts: Medical/Clinical
- Population group
- Biological samples
- Registers/Records/Accounts
Administrative information
Administrative information
Responsible department/unit:
Institute of Environmental Medicine
Funding
Funding
Funding agency:
- Swedish Research Council
Award number:
2007-7429
Topic and keywords
Topic and keywords
CESSDA Topic Classification:
Standard för svensk indelning av forskningsämnen 2025:
Keywords:
Publications
Publications
Citation:
de Faire U, Su J, Hua X, Frostegård A, Halldin M, Hellenius ML, Wikström M, Dahlbom I, Grönlund H, Frostegård J. Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men: effects on uptake of oxidized LDL in macrophages as a potential mechanism. J Autoimmun. 2010 Mar;34(2):73-9.
Citation:
Rosell MS, Hellénius ML, de Faire UH, Johansson GK. "Associations between diet and the metabolic syndrome vary with the validity of dietary intake data." , Am J Clin Nutr, 2003;78:84-90
