Neurofilament Light as a biomarker for neurotoxicity after isolated limb perfusion - a prospective feasibility trial

Name: Neurofilament Light as a biomarker for neurotoxicity after isolated limb perfusion - a prospective feasibility trial
Creator: Anna Corderfeldt Keiller
Published: 2024-09-09

Anna Corderfeldt Keiller

doi:10.5878/ykq2-1r07

Neurofilament Light as a biomarker for neurotoxicity after isolated limb perfusion - a prospective feasibility trial

https://doi.org/10.5878/ykq2-1r07

Explorative feasibility trial where patients scheduled for isolated limb perfusion were included. Blood samples were taken and a physiotherapist examined the patients pre- and post surgery for evaluation of nerve damage post isolated limb perfusion. Dataset contents: Measurements, blood samples, health status.

Download 9 documentation files (982.97 KiB)

Documentation files

Data PEK 4 all data codebook.docx
32.84 KiB
Data PEK 4 all data codebook.pdf
184.62 KiB
Data PEK 4 longitudinell codebook.docx
16.89 KiB
Data PEK 4 longitudinell codebook.pdf
56.76 KiB
PEK3 Alla analyser codebook.docx
109.04 KiB
PEK3 Alla analyser codebook.pdf
293.24 KiB
PEK3 longitudinella matningar codebook.docx
66.44 KiB
PEK3 longitudinella matningar codebook.pdf
202.89 KiB
Variabelförklaring.docx
20.24 KiB

Citation and access

Creator/Principal investigator(s):

Anna Corderfeldt Keiller - University of Gothenburg - Institute of Clinical Sciences
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Research principal:

University of Gothenburg
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Data contains personal data:

Yes

Type of personal data:

Health status

Code key exists:

Yes

Sensitive personal data:

Yes

Citation:

Data access level:

Access to data is restricted

Language:

Swedish

Method and outcome

Unit of analysis:

Time unit
Event/Process/Activity
Cells
Organ
Individual

Population:

Patients scheduled for isolated limb perfusion because of cancer tumours

Time method:

Longitudinal

Study design:

Experimental study

Description of study design:

Sampling procedure:

Total universe/Complete enumeration

Description of sampling:

Consecutive patients scheduled for isolated limb perfusion (ILP) that fulfilled inclusion criteria

Time period(s) investigated:

2019-04-12 - 2020-09-25

Variables:

192

Number of individuals/objects:

Data format/data structure:

Numeric
Text

Samples/material - Collected from scientific collection/biobank

Name:

Biobank Sverige ID: PS-0499-5-001

Type(s) of sample:

Blood samples

Data collection - Measurements and tests

Mode of collection:

Measurements and tests

Description of the mode of collection:

Hemodymamic patient monitor, blood samples and test results from physiotherapist

Time period(s) for data collection:

2019-04-11 - 2020-10-23

Data collector:

University of Gothenburg
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ROROpens in a new tab

Sample size:

Non response size:

Source of the data:

Biological samples

Sample

Name:

Blood gas

Description of sample:

Blood sampling from heart-lung machine and venous samples on 30 day follow up

Name:

Blood samples

Description of sample:

Neuronal markers

Geographic coverage

Geographic location:

Sweden

Geographic description:

Patients from all over Sweden

Administrative information

Responsible department/unit:

Institute of Clinical Sciences, Department of Surgery

Contributor(s):

Roger Olofsson Bagge - University of Gothenburg - Institute of Clinical Sciences
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Ethics Review:

Swedish Ethical Review Authority - 2019-01046

Topic and keywords

CESSDA Topic Classification:

Specific diseases, disorders and medical conditions

Standard för svensk indelning av forskningsämnen 2025:

Physiology and anatomy
Cancer and oncology

Keywords:

Neoplasms
Biomarkers
Extremities
Nervous system
Chemotherapy, cancer, regional perfusion
Skin neoplasms
Neurofilament proteins
Neurotoxicity syndromes
Sarcoma, myeloid
Myeloid sarcoma
Kontrollundersökning efter behandling för malignt melanom i huden

Publications

Citation:

Corderfeldt Keiller A, Axelsson M, Bragadottir G, Blennow K, Zetterberg H, Olofsson Bagge R. A prospective feasibility trial exploring novel biomarkers for neurotoxicity after isolated limb perfusion. Perfusion. 2023;0(0). doi:10.1177/02676591231213506

DOI:
10.1177/02676591231213506Opens in a new tab

Contact

Anna Corderfeldt Keilleranna.corderfeldt@gu.seOpens in a new tab

Metadata

Selected format to export the metadata

Version 1

Neurofilament Light as a biomarker for neurotoxicity after isolated limb perfusion - a prospective feasibility trial

Documentation files

Citation and access

Creator/Principal investigator(s):

Research principal:

Data contains personal data:

Type of personal data:

Code key exists:

Sensitive personal data:

Citation:

Data access level:

Language:

Method and outcome

Unit of analysis:

Population:

Time method:

Study design:

Description of study design:

Sampling procedure:

Description of sampling:

Time period(s) investigated:

Variables:

Number of individuals/objects:

Data format/data structure:

Samples/material - Collected from scientific collection/biobank

Name:

Type(s) of sample:

Data collection - Measurements and tests

Mode of collection:

Description of the mode of collection:

Time period(s) for data collection:

Data collector:

Sample size:

Non response size:

Source of the data:

Sample

Name:

Description of sample:

Name:

Description of sample:

Geographic coverage

Geographic location:

Geographic description:

Administrative information

Responsible department/unit:

Contributor(s):

Ethics Review:

Topic and keywords

CESSDA Topic Classification:

Standard för svensk indelning av forskningsämnen 2025:

Keywords:

Publications

Citation:

DOI:

Contact

Metadata