PIVUS - Prospective Investigation of the Vasculature in Uppsala Seniors

The PIVUS study started in 2001 with the primary aim to investigate the predicive power of different measurements of endothelial function and arterial compliance in a random sample of 1000 subjects aged 70 living in the community of Uppsala. As secondary aims, the study also included measurements of cardiac function and structure by ultrasound and MRI, evaluation of atherosclerosis by ultrasound and MRI, 7 day food intake recordings, detailed ECG analysis, cardiovascular autonomic function, body composition by DXA, DNA analysis and lung function, as well as a number of biochemical markers. Purpose: To study the pathogenesis of atherosclerosis and its related diseases 1016 individuals all aged 70 (50%) were investigated 2001-2003. Reinvestigations were performed at age 75 and 80.