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Image files from neuronal autoantibody screening for patients undergoing memory impairment investigations

https://doi.org/10.48723/m0cq-4k94
This dataset contains image files from 1021 memory clinic patients that have undergone screening for 5 different neuronal autoantibodies. The files are in the .nd2 format, owned by Nikon, but can be accessed through multiple open-source platforms, for example ImageJ, BioFormats or RBioFormats. For each individual, there are five files with two duplicates (two for each antigen). Each file contains three images, 2048+2048 pixels in size, that have been taken from random locations in a well in a microscopy-grade 96-well plate. The cells in the images are 293 MSR cells (ThermoFisher). For the full protocol, see https://github.com/jtheorell/Laboratory-protocols.
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Documentation files

Citation and access

Data access level:

Creator/​Principal investigator(s):

Research principal:

Data contains personal data:

Yes

Type of personal data:

There will be no identifiable data published with the dataset, but a local copy of the dataset kept with us will retain the pseudonym from the study. This pseudonym is the reason that the dataset requires a higher security level than fully open access enables.

Code key exists:

Yes

Sensitive personal data:

Yes

Citation:

Language:

Copyright:

No

Method and outcome

Population:

Patients undergoing investigations because of memory impairment

Time method:

Study design:

  • Diagnostic study

Time period(s) investigated:

Number of individuals/​objects:

1021

Data format/​data structure:

Samples/material Existing from scientific collection/biobank

Name:

GEDOC

Type(s) of sample:

Serum

Data collection Biological tests

Mode of collection:

Biological tests

Time period(s) for data collection:

2019 - 2023

Data collector:

Sample size:

211

Source of the data:

  • Biological samples

Geographic coverage

Geographic location:

Geographic description:

For the memory clinics, Karolinska University hospital, the catchment area for early or rapidly progressing memory impairment is the whole Stockholm Region, with 2 100 000 inhabitants. For a smaller sub-region, with approximately 3-500 000 individuals, all cases of memory impairment are seen at the Karolinska University hospital. This means that the dataset is somewhat skewed towards more severe cases, and thus might include an enrichment of autoimmune encephalitis.

Lowest geographic unit:

Municipality

Highest geographic unit:

Region

Administrative information

Responsible department/​unit:

Department of Medicine, Huddinge [H7]

Contributor(s):

  • Amanda Freitas-Huhtamäki - Karolinska Institutet
  • Nicole Kleebauer - Karolinska Institutet
  • Alexandra Gardner - Karolinska Institutet

Ethical Review

Reviewer:

Registration number:

2022-03556-01

Reviewer:

  • Stockholm Ethical Review Board

Registration number:

2011_1987-31

Funding

Funding agency:

  • Swedish Wenner-Gren foundations

Award number:

FT2021-0005

Funding agency:

  • Swedish Wenner-Gren foundations

Award number:

WUP2022-003

Funding agency:

  • Alzheimerfonden

Award number:

AF-981112

Topic and keywords

CESSDA topic classification:

Swedish Standard Classification of Research Subjects 2025:

Keywords:

Relations

Is supplemented by:

jtheorell / Laboratory-protocols

Contact

Metadata

Version 1
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Version 1 published: