Uppsala Longitudinal Study of Adult Men (ULSAM)

Name: Uppsala Longitudinal Study of Adult Men (ULSAM)
Creator: Peter Nordström
Published: 2015-04-23

Peter Nordström

Uppsala Longitudinal Study of Adult Men (ULSAM)

Uppsala Longitudinal Study of Adult Men (ULSAM) is a unique, ongoing, longitudinal, epidemiologic study based on all available men, born between 1920 and 1924 and living in Uppsala County, Sweden. The aim of Uppsala Study of Adult Men (ULSAM) is to investigate the risk factors for common diseases, including biochemical markers, variations in the genome and life style factors. ULSAM started as a health investigation, focused at identifying metabolic risk factors for cardiovascular disease, to which all 50 year-old men living in Uppsala in 1970 were invited. Of these, 82% (2322 men) participated in the investigation. The men were thereafter investigated again at ages 60, 70, 77, 82, 88 and 93 years. In the 93 years investigation, which was completed in spring 2015, even spouses to the men from original cohort have participated. ULSAM is focused on several areas with a wide range of phenotypes collected. These areas include glucose and insulin metabolism, blood pressure, anthropometry, lipids and fatty acid composition, diet, cognitive function, socio-economic factors, heredity, medical history, and common risk factors for cardiovascular disease. In the latest investigation we are particularly focusing on the factors leading to healthy ageing. The longitudinal design of the study contributes to the collection of the same (or similar) phenotypes at several points in time. The loss of follow up end points is very low due to yearly matching with official cause-of-death and hospital discharge registries. Very important research area in ULSAM is analysis of genetic factors affecting common diseases. We have DNA samples available from more than 1200 men. Using modern genotyping technologies, these samples have been analyzed for over 2.5 million SNPs. We are also planning to perform whole genome sequencing for all individuals with DNA samples available. Large number of researchers are using ULSAM data in their studies. ULSAM is involved in several international collaborations as well. Over 300 articles have been published from ULSAM initiation in 1970 and at least 30 doctoral theses explored data collected in our study.

Go to data source

https://www.maelstrom-research.org/study/ulsam

Citation and access

Data contains personal data:

Yes

Type of personal data:

The data are pseudonymized and contain indirect identifiers as well as different health, clinical and genetic data

Code key exists:

Yes

Sensitive personal data:

Yes

Citation:

Language:

Method and outcome

Unit of analysis:

Individual

Population:

Men born 1920-1924 in Uppsala county

Time method:

Study design:

Observational study

Sampling procedure:

Total universe/Complete enumeration

Time period(s) investigated:

Description of the response rate/participation rate:

Age 50: 2322 individuals Age 60: 1860 individuals Age 70: 1221 individuals Age 77: 839 individuals Age 82: 530 individuals Age 88: 354 individuals Age 93: 168 individuals

Data format/data structure:

Numeric

Samples/material - Existing from scientific collection/biobank

Name:

Data collections - 7 collections

Data collection

Description of the mode of collection:

Focus group: face-to-face Psychological measurements and tests Self-administered questionnaire: paper Participant laboratory observation Laboratory observation Measurements and tests Face-to-face interview Telephone interview

Time period(s) for data collection:

1970 - 1973

Number of responses:

2322

Source of the data:

Registers/Records/Accounts: Medical/Clinical
Population group
Biological samples
Registers/Records/Accounts

Data collection

Description of the mode of collection:

Focus group: face-to-face Psychological measurements and tests Self-administered questionnaire: paper Participant laboratory observation Laboratory observation Measurements and tests Face-to-face interview Telephone interview

Time period(s) for data collection:

1980 - 1984

Number of responses:

1860

Source of the data:

Registers/Records/Accounts: Medical/Clinical
Population group
Biological samples
Registers/Records/Accounts

Data collection

Description of the mode of collection:

Focus group: face-to-face Psychological measurements and tests Self-administered questionnaire: paper Participant laboratory observation Laboratory observation Measurements and tests Face-to-face interview Telephone interview

Time period(s) for data collection:

1991 - 1995

Number of responses:

1221

Source of the data:

Registers/Records/Accounts: Medical/Clinical
Population group
Biological samples
Registers/Records/Accounts

Data collection

Description of the mode of collection:

Focus group: face-to-face Psychological measurements and tests Self-administered questionnaire: paper Participant laboratory observation Laboratory observation Measurements and tests Face-to-face interview Telephone interview

Time period(s) for data collection:

1997 - 2001

Number of responses:

839

Source of the data:

Registers/Records/Accounts: Medical/Clinical
Population group
Biological samples
Registers/Records/Accounts

Data collection

Description of the mode of collection:

Focus group: face-to-face Psychological measurements and tests Self-administered questionnaire: paper Participant laboratory observation Laboratory observation Measurements and tests Face-to-face interview Telephone interview

Time period(s) for data collection:

2003 - 2005

Number of responses:

530

Source of the data:

Registers/Records/Accounts: Medical/Clinical
Population group
Biological samples
Registers/Records/Accounts

Data collection

Description of the mode of collection:

Focus group: face-to-face Psychological measurements and tests Self-administered questionnaire: paper Participant laboratory observation Laboratory observation Measurements and tests Face-to-face interview Telephone interview

Time period(s) for data collection:

2008 - 2009

Number of responses:

354

Source of the data:

Registers/Records/Accounts: Medical/Clinical
Population group
Biological samples
Registers/Records/Accounts

Data collection

Description of the mode of collection:

Focus group: face-to-face Psychological measurements and tests Self-administered questionnaire: paper Participant laboratory observation Laboratory observation Measurements and tests Face-to-face interview Telephone interview

Time period(s) for data collection:

2014 - 2015

Number of responses:

168

Source of the data:

Registers/Records/Accounts: Medical/Clinical
Population group
Biological samples
Registers/Records/Accounts

Geographic coverage

Geographic location:

Sweden

Geographic description:

Uppsala county

Lowest geographic unit:

County (NUTS 3)

Highest geographic unit:

County (NUTS 3)

Administrative information

Responsible department/unit:

Department of Public Health and Caring Sciences

PURL:

https://www.maelstrom-research.org/study/ulsam

Ethics Review 1:

Uppsala - Dnr 251/90

ULSAM-70: Dnr 251/90, godkänt 1991-08-21

Ethics Review 2:

Uppsala - Dnr 2013/350

ULSAM-93: Dnr 2013/350, godkänt 2013-10-23

Topic and keywords

Relations

Homepage:

Uppsala Longitudinal Study of Adult Men (ULSAM)Opens in a new tab

Publications

Link to publication list:

https://pubmed.ncbi.nlm.nih.gov/collections/61573411/?sort=pubdateOpens in a new tab

Contact

Vilmantas Giedraitisvilmantas.giedraitis@uu.se

Peter Nordströmpeter.nordstrom@pubcare.uu.se

Metadata

Version 1

Uppsala Longitudinal Study of Adult Men (ULSAM)

Citation and access

Data access level:

Creator/Principal investigator(s):

Research principal:

Data contains personal data:

Type of personal data:

Code key exists:

Sensitive personal data:

Citation:

Language:

Method and outcome

Unit of analysis:

Population:

Time method:

Study design:

Sampling procedure:

Time period(s) investigated:

Description of the response rate/participation rate:

Data format/data structure:

Samples/material - Existing from scientific collection/biobank

Name:

Data collections - 7 collections

Data collection

Description of the mode of collection:

Time period(s) for data collection:

Number of responses:

Source of the data:

Data collection

Description of the mode of collection:

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Source of the data:

Data collection

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Data collection

Description of the mode of collection:

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Source of the data:

Data collection

Description of the mode of collection:

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Source of the data:

Data collection

Description of the mode of collection:

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Number of responses:

Source of the data:

Data collection

Description of the mode of collection:

Time period(s) for data collection:

Number of responses:

Source of the data:

Geographic coverage

Geographic location:

Geographic description:

Lowest geographic unit:

Highest geographic unit:

Administrative information

Responsible department/unit:

PURL:

Ethics Review 1:

Ethics Review 2:

Topic and keywords

CESSDA Topic Classification:

Standard för svensk indelning av forskningsämnen 2025:

Keywords:

Relations

Homepage:

Publications

Link to publication list:

Contact

Metadata