Uppsala Longitudinal Study of Adult Men (ULSAM)
Uppsala Longitudinal Study of Adult Men (ULSAM) is a unique, ongoing, longitudinal, epidemiologic study based on all available men, born between 1920 and 1924 and living in Uppsala County, Sweden. The aim of Uppsala Study of Adult Men (ULSAM) is to investigate the risk factors for common diseases, including biochemical markers, variations in the genome and life style factors.
ULSAM started as a health investigation, focused at identifying metabolic risk factors for cardiovascular disease, to which all 50 year-old men living in Uppsala in 1970 were invited. Of these, 82% (2322 men) participated in the investigation. The men were thereafter investigated again at ages 60, 70, 77, 82, 88 and 93 years. In the 93 years investigation, which was completed in spring 2015, even spouses to the men from original cohort have participated.
ULSAM is focused on several areas with a wide range of phenotypes collected. These areas include glucose and insulin metabolism, blood pressure, anthropometry, lipids and fatty acid composition, diet, cognitive function, socio-economic factors, heredity, medical history, and common risk factors for cardiovascular disease. In the latest investigation we are particularly focusing on the factors leading to healthy ageing.
The longitudinal design of the study contributes to the collection of the same (or similar) phenotypes at several points in time. The loss of follow up end points is very low due to yearly matching with official cause-of-death and hospital discharge registries. Very important research area in ULSAM is analysis of genetic factors affecting common diseases. We have DNA samples available from more than 1200 men. Using modern genotyping technologies, these samples have been analyzed for over 2.5 million SNPs. We are also planning to perform whole genome sequencing for all individuals with DNA samples available.
Large number of researchers are using ULSAM data in their studies. ULSAM is involved in several international collaborations as well. Over 300 articles have been published from ULSAM initiation in 1970 and at least 30 doctoral theses explored data collected in our study.
Go to data source
https://www.maelstrom-research.org/study/ulsam
Citation and access
Citation and access
Data access level:
Creator/Principal investigator(s):
Research principal:
Data contains personal data:
Yes
Type of personal data:
The data are pseudonymized and contain indirect identifiers as well as different health, clinical and genetic data
Code key exists:
Yes
Sensitive personal data:
Yes
Citation:
Method and outcome
Method and outcome
Unit of analysis:
Population:
Men born 1920-1924 in Uppsala county
Time method:
Study design:
- Observational study
Sampling procedure:
Time period(s) investigated:
Description of the response rate/participation rate:
Age 50: 2322 individuals
Age 60: 1860 individuals
Age 70: 1221 individuals
Age 77: 839 individuals
Age 82: 530 individuals
Age 88: 354 individuals
Age 93: 168 individuals
Data format/data structure:
Samples/material - Existing from scientific collection/biobank
Samples/material - Existing from scientific collection/biobank
Name:
Data collections - 7 collections
Data collections - 7 collections
Data collection
Data collection
Description of the mode of collection:
Focus group: face-to-face
Psychological measurements and tests
Self-administered questionnaire: paper
Participant laboratory observation
Laboratory observation
Measurements and tests
Face-to-face interview
Telephone interview
Time period(s) for data collection:
1970 - 1973
Number of responses:
2322
Source of the data:
- Registers/Records/Accounts: Medical/Clinical
- Population group
- Biological samples
- Registers/Records/Accounts
Data collection
Data collection
Description of the mode of collection:
Focus group: face-to-face
Psychological measurements and tests
Self-administered questionnaire: paper
Participant laboratory observation
Laboratory observation
Measurements and tests
Face-to-face interview
Telephone interview
Time period(s) for data collection:
1980 - 1984
Number of responses:
1860
Source of the data:
- Registers/Records/Accounts: Medical/Clinical
- Population group
- Biological samples
- Registers/Records/Accounts
Data collection
Data collection
Description of the mode of collection:
Focus group: face-to-face
Psychological measurements and tests
Self-administered questionnaire: paper
Participant laboratory observation
Laboratory observation
Measurements and tests
Face-to-face interview
Telephone interview
Time period(s) for data collection:
1991 - 1995
Number of responses:
1221
Source of the data:
- Registers/Records/Accounts: Medical/Clinical
- Population group
- Biological samples
- Registers/Records/Accounts
Data collection
Data collection
Description of the mode of collection:
Focus group: face-to-face
Psychological measurements and tests
Self-administered questionnaire: paper
Participant laboratory observation
Laboratory observation
Measurements and tests
Face-to-face interview
Telephone interview
Time period(s) for data collection:
1997 - 2001
Number of responses:
839
Source of the data:
- Registers/Records/Accounts: Medical/Clinical
- Population group
- Biological samples
- Registers/Records/Accounts
Data collection
Data collection
Description of the mode of collection:
Focus group: face-to-face
Psychological measurements and tests
Self-administered questionnaire: paper
Participant laboratory observation
Laboratory observation
Measurements and tests
Face-to-face interview
Telephone interview
Time period(s) for data collection:
2003 - 2005
Number of responses:
530
Source of the data:
- Registers/Records/Accounts: Medical/Clinical
- Population group
- Biological samples
- Registers/Records/Accounts
Data collection
Data collection
Description of the mode of collection:
Focus group: face-to-face
Psychological measurements and tests
Self-administered questionnaire: paper
Participant laboratory observation
Laboratory observation
Measurements and tests
Face-to-face interview
Telephone interview
Time period(s) for data collection:
2008 - 2009
Number of responses:
354
Source of the data:
- Registers/Records/Accounts: Medical/Clinical
- Population group
- Biological samples
- Registers/Records/Accounts
Data collection
Data collection
Description of the mode of collection:
Focus group: face-to-face
Psychological measurements and tests
Self-administered questionnaire: paper
Participant laboratory observation
Laboratory observation
Measurements and tests
Face-to-face interview
Telephone interview
Time period(s) for data collection:
2014 - 2015
Number of responses:
168
Source of the data:
- Registers/Records/Accounts: Medical/Clinical
- Population group
- Biological samples
- Registers/Records/Accounts
Geographic coverage
Geographic coverage
Geographic location:
Geographic description:
Uppsala county
Lowest geographic unit:
County (NUTS 3)
Highest geographic unit:
County (NUTS 3)
Administrative information
Administrative information
Responsible department/unit:
Department of Public Health and Caring Sciences
Identifiers
Identifiers
Ethical Review
Ethical Review
Reviewer:
- Uppsala Ethical Review Board
Registration number:
Dnr 251/90
Ethical review information:
ULSAM-70: Dnr 251/90, godkänt 1991-08-21
Reviewer:
- Uppsala Ethical Review Board
Registration number:
Dnr 2013/350
Ethical review information:
ULSAM-93: Dnr 2013/350, godkänt 2013-10-23
Topic and keywords
Topic and keywords
CESSDA topic classification:
Swedish Standard Classification of Research Subjects 2025:
Keywords:
Relations
Relations
Publications
Publications
Link to publication list:
Metadata
Metadata
Version 1
