SIMPLER - Swedish Infrastructure for Medical Population-Based Life-Course and Environmental Research

SIMPLER is an indvidual-based database and biobank primarily for epidemiological research. The database consists of two population-based cohorts, Swedish Mammography Cohort and Cohort of Swedish Menand its clinical subcohorts. All together they cover a total of approximately 110 000 persons born 1914–1952, from the counties of Uppsala, Västmanland and Örebro. Data collection from the participants has been made continuously since 1987, through regular mailings of questionnaires and surveys, as well as linking to register-based data. A biobank with DNA and other biological samples from a large number of the participants is available. Data and samples from SIMPLER are used for research into areas such as cancer, neurological disease, circulatory disease, digestive system disease, kidney disease, diabetes and osteoporosis. The SIMPLER consortium is coordinated by Uppsala University, with participation by Chalmers University of Technology, Karolinska Institutet and Örebro University. Director is Karl Michaëlsson, Uppsala universitet.